ID   V9FZ49_PHYPR            Unreviewed;       532 AA.
AC   V9FZ49;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Threonine synthase {ECO:0000313|EMBL:ETI56775.1};
GN   ORFNames=F443_00830 {ECO:0000313|EMBL:ETI56775.1};
OS   Phytophthora parasitica P1569.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=1317065 {ECO:0000313|EMBL:ETI56775.1, ECO:0000313|Proteomes:UP000018721};
RN   [1] {ECO:0000313|EMBL:ETI56775.1, ECO:0000313|Proteomes:UP000018721}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P1569 {ECO:0000313|EMBL:ETI56775.1,
RC   ECO:0000313|Proteomes:UP000018721};
RG   The Broad Institute Genomics Platform;
RA   Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA   Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Phytophthora parasitica P1569.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR604450-51};
CC   -!- SIMILARITY: Belongs to the threonine synthase family.
CC       {ECO:0000256|ARBA:ARBA00005517}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETI56775.1}.
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DR   EMBL; ANIZ01000141; ETI56775.1; -; Genomic_DNA.
DR   AlphaFoldDB; V9FZ49; -.
DR   EnsemblProtists; ETI56775; ETI56775; F443_00830.
DR   eggNOG; KOG2616; Eukaryota.
DR   HOGENOM; CLU_015170_1_0_1; -.
DR   OrthoDB; 275600at2759; -.
DR   Proteomes; UP000018721; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd01560; Thr-synth_2; 1.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   Gene3D; 3.90.1380.10; Threonine synthase, N-terminal domain; 1.
DR   InterPro; IPR029144; Thr_synth_N.
DR   InterPro; IPR037158; Thr_synth_N_sf.
DR   InterPro; IPR004450; Thr_synthase-like.
DR   InterPro; IPR001926; TrpB-like_PALP.
DR   InterPro; IPR036052; TrpB-like_PALP_sf.
DR   NCBIfam; TIGR00260; thrC; 1.
DR   PANTHER; PTHR42690; THREONINE SYNTHASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR42690:SF1; THREONINE SYNTHASE-LIKE 2; 1.
DR   Pfam; PF00291; PALP; 1.
DR   Pfam; PF14821; Thr_synth_N; 1.
DR   SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239}; Membrane {ECO:0000256|SAM:Phobius};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR604450-51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018721};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        511..528
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          3..84
FT                   /note="Threonine synthase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14821"
FT   DOMAIN          105..421
FT                   /note="Tryptophan synthase beta chain-like PALP"
FT                   /evidence="ECO:0000259|Pfam:PF00291"
FT   MOD_RES         118
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604450-51"
SQ   SEQUENCE   532 AA;  58550 MW;  CFA1D851998ABD8D CRC64;
     MVHYRSTRGG VRGLSFEQAV LTGLASDRGL LVPEVNEFPT LPADALEKWA SLSYQELAVE
     VMHLFIDESE ISRDQLRQLV AKSYNSTTFR AEEVAPVVKV TDQMLVLELF HGPTFAFKDI
     ALQFLGNLFE FFLKRKNEAL PAGASKHQIT VVGATSGDTG SSAIYGLRGK ENVEVFILFP
     EGRVSAIQQR QMTTVLDQNI HNVAVKGTFD DCQAIVKDLF ANADFKAKYN LGAVNSINFA
     RILAQIVYYV WAYFRAREQG VSGEVAFSVP TGNFGDILAG FYAKKLGVPI GKLIVATNEN
     DILHRFFSTG KYHRRDIEHT ISPSMDICVS SNFERYLFAL SGENHDILRG WMQGFEQTGE
     LTISGELLTK AQDEMASYAV LQEEVRSTIA EYKKVHQHLF DPHSAIGAAA AMHFGQDNLA
     DKPNSAVVVV GTAHYDKFLP VVSKALGVDE SEIQQHPILK ALESLPTRLS VAKNSSATVA
     EHIRKTIAIK NQKACSNCFS LWTSAPTECK LATLALAAAT VAAAFFVARR SK
//