ID V9GYS9_HUMAN Unreviewed; 295 AA.
AC V9GYS9;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Multimerin 2 {ECO:0000313|Ensembl:ENSP00000477052.1};
DE Flags: Fragment;
GN Name=MMRN2 {ECO:0000313|Ensembl:ENSP00000477052.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000477052.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000477052.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000477052.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC025268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL136982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; V9GYS9; -.
DR SMR; V9GYS9; -.
DR MassIVE; V9GYS9; -.
DR PeptideAtlas; V9GYS9; -.
DR Antibodypedia; 16004; 123 antibodies from 25 providers.
DR Ensembl; ENST00000610081.5; ENSP00000477052.1; ENSG00000173269.14.
DR UCSC; uc057uqn.1; human.
DR HGNC; HGNC:19888; MMRN2.
DR VEuPathDB; HostDB:ENSG00000173269; -.
DR GeneTree; ENSGT01030000234633; -.
DR HOGENOM; CLU_082300_0_0_1; -.
DR ChiTaRS; MMRN2; human.
DR Proteomes; UP000005640; Chromosome 10.
DR Bgee; ENSG00000173269; Expressed in subcutaneous adipose tissue and 185 other cell types or tissues.
DR ExpressionAtlas; V9GYS9; baseline and differential.
DR InterPro; IPR011489; EMI_domain.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR PANTHER; PTHR15427:SF6; MULTIMERIN-2; 1.
DR Pfam; PF07546; EMI; 1.
DR PROSITE; PS51041; EMI; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Proteomics identification {ECO:0007829|MaxQB:V9GYS9,
KW ECO:0007829|PeptideAtlas:V9GYS9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 28..106
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 295
FT /evidence="ECO:0000313|Ensembl:ENSP00000477052.1"
SQ SEQUENCE 295 AA; 32943 MW; 84EA17B0512CB345 CRC64;
MGTSASWAGG MGIKGQPEAA KSWRKPKQSN WCPYPMSKLV TLLALCKTEK FLIHSQQPCP
QGAPDCQKVK VMYRMAHKPV YQVKQKVLTS LAWRCCPGYT GPNCEHHDSM AIPEPADPGD
SHQEPQDGPV SFKPGHLAAV INEVEVQQEQ QEHLLGDLQN DVHRVADSLP GLWKALPGNL
TAAVMEANQT GHEFPDRSLE QVLLPHVDTF LQVHFSPIWR SFNQSLHSLT QAIRNLSLDV
EANRQAISRV QDSAVARADF QELGAKFEAK VQENTQRVGQ LRQDVEDRLH AQHFT
//
