ID   V9I775_APICE            Unreviewed;       758 AA.
AC   V9I775;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   13-SEP-2023, entry version 21.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=ACCB00092.4 {ECO:0000313|EMBL:AEY56935.1};
OS   Apis cerana (Indian honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC   Anthophila; Apidae; Apis.
OX   NCBI_TaxID=7461 {ECO:0000313|EMBL:AEY56935.1};
RN   [1] {ECO:0000313|EMBL:AEY56935.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:AEY56935.1};
RA   Sun L., Zheng H., Wang Y., Xie X., Zhu Y., Gu W., Wang S.;
RT   "Decoding the brain transcriptome of the Eastern honeybee (Apis cerana)
RT   based on pyrosequencing.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; JR036123; AEY56935.1; -; mRNA.
DR   AlphaFoldDB; V9I775; -.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        402..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        445..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        540..561
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        573..596
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        647..665
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          51..128
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   758 AA;  86981 MW;  D966C189F8C8C2B5 CRC64;
     MGSLFRSEEM TLCQLFLQSE AAYACVSELG ELGLVQFRDL NPDVNAFQRK FVNEVRRCDE
     MERKLRYLEK EIKKDGIPML DTGENPEAPQ PREMIDLEAT FEKLENELRE VNQNAETLKR
     NFLELTELKH ILRKTQVFFD EQEHAGLNPT ESMTRALISD DNIARQTALG PVQLGFVAGV
     ILRERIPAFE RMLWRACRGN VFLRQAEIET PLEDPSTGDQ VFKSVFIIFF QGDQLKTRVK
     KICEGFRATL YPCPEAPADR REMAMGVMTR IEDLNTVLGQ TQDHRHRVLV AAAKNIKNWF
     VKVRKIKAIY HTLNLFNLDV TQKCLIAECW VPVLDIEIIQ LALRRGTERS GSSVPPILNR
     MVTFEDPPTY NRTNKFTKGF QALIDAYGVA SYREMNPSPY TIITFPFLFA VMFGDTGHGL
     LMFLFGGWMV LKEKPLAAKK SDNEIWNIFF GGRYIIFLMG LFSMYTGLIY NDIFSKSLNI
     FGSYWRINYN FSTIDSNKEL QLNPSDKEQY LQIPYPIGMD PVWQLAENKI IFLNSYKMKI
     SIIFGVIHML FGVVIGLWNH MYFKRKLNIT CEFIPQIIFL VFLFLYMVLL MFIKWIKYGP
     DSDKIDPEHG PSCAPSVLIT FINMVLFKPG TAPKPCSPWM YGGQSGFQSF LVVIAVLCIP
     WMLLAKPIML MNNRKKQHYQ LNNHGTENGD VEGAVDAIQP ANGVPQGGGH KEEEEDMAEV
     FIHQGIHTIE YVLGSVSHTA SYLRLWALSL AHARKFKN
//