ID   V9K8Z9_CALMI            Unreviewed;      1408 AA.
AC   V9K8Z9;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=HEAT repeat-containing protein 1 {ECO:0000256|RuleBase:RU367065};
DE   Flags: Fragment;
OS   Callorhinchus milii (Ghost shark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX   NCBI_TaxID=7868 {ECO:0000313|EMBL:AFO94333.1};
RN   [1] {ECO:0000313|EMBL:AFO94333.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Ovary {ECO:0000313|EMBL:AFO94333.1};
RX   PubMed=24402279; DOI=10.1038/nature12826;
RG   International Elephant Shark Genome Sequencing Consortium;
RA   Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA   Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA   Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA   Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA   Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA   Wilson R.K., Brenner S., Warren W.C.;
RT   "Elephant shark genome provides unique insights into gnathostome
RT   evolution.";
RL   Nature 505:174-179(2014).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       {ECO:0000256|RuleBase:RU367065}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|RuleBase:RU367065}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family.
CC       {ECO:0000256|RuleBase:RU367065}.
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DR   EMBL; JW861816; AFO94333.1; -; mRNA.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; BAP28; 1.
DR   PANTHER; PTHR13457:SF1; HEAT REPEAT-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SUPFAM; SSF48371; ARM repeat; 3.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367065};
KW   Ribonucleoprotein {ECO:0000256|RuleBase:RU367065};
KW   Ribosome biogenesis {ECO:0000256|RuleBase:RU367065};
KW   rRNA processing {ECO:0000256|RuleBase:RU367065}.
FT   DOMAIN          238..353
FT                   /note="U3 small nucleolar RNA-associated protein 10 N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12397"
FT   REPEAT          518..556
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   NON_TER         1408
FT                   /evidence="ECO:0000313|EMBL:AFO94333.1"
SQ   SEQUENCE   1408 AA;  158127 MW;  8D040F0D399483BC CRC64;
     MTSLAYQLKR LALPQNDPSL LKRSEVASLL FTQSEAASID RDTFFAIGCT GLEELSGIDS
     SFEEFNSTLF SQASKDVERS VQSKSVNAQL DESILVFLTR LSPYFMLKPA QKCLEWLIQR
     FHIHLYNQDS LIGCVLPYHE TKVFVRVIQL LKLSDPTHRW HWLEPIQKPG VPLAKNTLIN
     HCYKDMSFMD FICNLVTKAG KAFLDNPGNA AQLRVLFSFY ASTIVLALDA VETITDTIIA
     KLLPYVQKGL KSSWEDYRSA TYMIICQLAV KVVMEASLVN TLAQQVSRTL AKKSSLTREG
     LSCLVILLQN QKRENISKKT FAYLCSVPDL STVLQDIDAQ YNVSPLLHYF LPKLLHSVTA
     EAAEEQEEHS SCQTRVKLLE AILQSVTLEN NLGETLVNVL IDDYISLWTT NDSSSDTPSA
     FNQKIKPLVR LLETRYPKAY DAALEERLRT ITSPREQDVF NQFVSLSLSS AKHQLLADSD
     TSLLLSLNHP QPAVRNFAVQ HLKEIIESSQ GGFDDLFLKD SILQRLKDDT PLVVLAALQA
     LKAFSGPLGQ EDTVSHILSL FHQVDLTEND QWCSVLEEAI MILSTGGLLD GNEVLTGQVL
     TELLPYVILT NPDRQSAEQK ITVFIANSGL CSLTPLLHGW PEALKDAIEC SKSSRLVGEA
     NEKLIQILVT NMCQMEPSTK TWTVEILVQF AEKESSNPRQ NLIFSVLSFA LVQALEKQPE
     SGSFQIALRV FGFLEKKLRK LITKSEHLEE VSENRCLDSD GGNTSLAQLL TELVKTPQAG
     NTEPGLILTL LLKNFIVAFE PPISLPKGQT WWNPESLDKQ NCDYLRLLIG LFDIIICGSS
     EGSLVGSFRI LMQLLFQTHL PNTNSLFMFL NLLWTYNFNL GNQINCTINA VLQTRALYMG
     RVLLTDQSAG QRGMLASLSS PVLISLVICL GSPVREVRRG AIGCLQTLML LRGTVFYQVI
     DKLVNLGEEI ISDHRHLPQV FSSLFEQLLT QSKPNAQNKR LTEALENFMQ CIVDPEWPSY
     IARCLLNTLE EVNGELMMSK LRPLLERFLE KESGTFRKDE ALLLHMILRK YNKYSAPFLA
     THIRSMNFFL SAMNNSKELY RGLPTLQVIA LGQITKEFFA ALPDGKIQQK LLGVLFDLLV
     QCKNPACAQL IGNVFKGITV DAEQIAQEFG SLQKPQSQAT VQQKRRQKML QRKSQELQGA
     EPVPPIDNVY WQRVTLILEL MQHKKKLKRP QILIPALFSL LSRCLDPSLS EEASLEYTKQ
     LLLNCLLNLC QKLSPDGTKI SKDVLDEEKF NVELIVQCVR GSNVPQTHHH ALLLLGTAAG
     IFPDKVLHNI MPIFTFMGAN VMRLDDSYSF KVINNTVKTV IPALIQANDE GSVEIKEHVN
     KVVTNIIHVF VDALPHVPEH RRLPILSQ
//