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Database: UniProt
Entry: V9K9V4_CALMI
LinkDB: V9K9V4_CALMI
Original site: V9K9V4_CALMI 
ID   V9K9V4_CALMI            Unreviewed;       604 AA.
AC   V9K9V4;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   RecName: Full=Netrin-1 {ECO:0000256|ARBA:ARBA00015919};
GN   Name=ntn1 {ECO:0000313|Ensembl:ENSCMIP00000043882.1};
OS   Callorhinchus milii (Ghost shark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX   NCBI_TaxID=7868 {ECO:0000313|EMBL:AFO94636.1};
RN   [1] {ECO:0000313|Proteomes:UP000314986}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17185593; DOI=10.1126/science.1130708;
RA   Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA   Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA   Brenner S.;
RT   "Ancient noncoding elements conserved in the human genome.";
RL   Science 314:1892-1892(2006).
RN   [2] {ECO:0000313|Proteomes:UP000314986}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17407382;
RA   Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA   Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA   Brenner S.;
RT   "Survey sequencing and comparative analysis of the elephant shark
RT   (Callorhinchus milii) genome.";
RL   PLoS Biol. 5:E101-E101(2007).
RN   [3] {ECO:0000313|EMBL:AFO94636.1, ECO:0000313|Proteomes:UP000314986}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Intestine {ECO:0000313|EMBL:AFO94636.1};
RX   PubMed=24402279; DOI=10.1038/nature12826;
RG   International Elephant Shark Genome Sequencing Consortium;
RA   Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA   Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA   Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA   Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA   Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA   Wilson R.K., Brenner S., Warren W.C.;
RT   "Elephant shark genome provides unique insights into gnathostome
RT   evolution.";
RL   Nature 505:174-179(2014).
RN   [4] {ECO:0000313|Ensembl:ENSCMIP00000043882.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   EMBL; JW862119; AFO94636.1; -; mRNA.
DR   RefSeq; XP_007886704.1; XM_007888513.1.
DR   Ensembl; ENSCMIT00000044510.1; ENSCMIP00000043882.1; ENSCMIG00000018174.1.
DR   GeneID; 103175455; -.
DR   KEGG; cmk:103175455; -.
DR   CTD; 30227; -.
DR   GeneTree; ENSGT00940000153882; -.
DR   OrthoDB; 2916807at2759; -.
DR   Proteomes; UP000314986; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   CDD; cd00055; EGF_Lam; 3.
DR   CDD; cd03579; NTR_netrin-1_like; 1.
DR   Gene3D; 2.40.50.120; -; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 2.10.25.10; Laminin; 2.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR008211; Laminin_N.
DR   InterPro; IPR002049; LE_dom.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR018933; Netrin_module_non-TIMP.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   PANTHER; PTHR10574:SF378; NETRIN-1; 1.
DR   PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR   Pfam; PF00053; Laminin_EGF; 3.
DR   Pfam; PF00055; Laminin_N; 1.
DR   Pfam; PF01759; NTR; 1.
DR   SMART; SM00643; C345C; 1.
DR   SMART; SM00180; EGF_Lam; 3.
DR   SMART; SM00136; LamNT; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 3.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF50242; TIMP-like; 1.
DR   PROSITE; PS01248; EGF_LAM_1; 1.
DR   PROSITE; PS50027; EGF_LAM_2; 1.
DR   PROSITE; PS51117; LAMININ_NTER; 1.
DR   PROSITE; PS50189; NTR; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00460};
KW   Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW   ECO:0000256|PROSITE-ProRule:PRU00460};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314986};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..604
FT                   /note="Netrin-1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5040664328"
FT   DOMAIN          47..284
FT                   /note="Laminin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51117"
FT   DOMAIN          404..453
FT                   /note="Laminin EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50027"
FT   DOMAIN          472..601
FT                   /note="NTR"
FT                   /evidence="ECO:0000259|PROSITE:PS50189"
FT   DISULFID        404..416
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT   DISULFID        406..423
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT   DISULFID        425..434
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT   DISULFID        437..451
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ   SEQUENCE   604 AA;  68045 MW;  2770D16CE6E7C90E CRC64;
     MLMSVWELVC AFVGVTFLVE GVRGAYGMSM FAAQQTPPDP CYDETGNPRR CIPDFVNSAF
     GKEVRVSSTC GKPPSRYCVV AEKGDQRSRT CHVCDSTDPK KGRPPAFLTD LNNPHNLTCW
     QSESYPQAPQ NVTLTLSLGK KFEVTYVSLQ FCSPRPESMV IYKSMDYGKA WVPFQFYSTQ
     CRKMFGKANK APITKQNEQE AICTDSHTDM HPLTGGLIAF STLDGRPSAH DFDNSPVLQD
     WVTATDIKVV FSRLHTFGDE NEDDPELARE SYYYAVSDLQ VGGRCKCNGH ASRCIRDRDG
     HLVCDCKHHT AGPECDRCKP FHYDRPWQRA TAREANECVA CNCNLHARRC RFNMELFKLS
     GRKSGGVCLN CRHNTAGRHC HYCKEGYYRD MTKPITHRKA CKACDCHPVG AAGKTCNQTT
     GQCPCKDGVT GITCNRCAKG YQQSRSPIAP CIKIPMVTPA TAISSTEEHA DCDSYCKASK
     GKLKINMKKY CKKDYAVQAH ILKAEKASDW WKFIVNIISV YKQGGKRIRR GDQFLWVRSK
     DIACRCPKIK TGKKYLILGN DEDSPDQNGV VANKNSLVIQ WRDTWARRLR KFQQREKKGK
     CKKA
//
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