ID   V9KAY5_CALMI            Unreviewed;       927 AA.
AC   V9KAY5;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Protein unc-45 homolog B {ECO:0000256|ARBA:ARBA00020768};
OS   Callorhinchus milii (Ghost shark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX   NCBI_TaxID=7868 {ECO:0000313|EMBL:AFO94882.1};
RN   [1] {ECO:0000313|EMBL:AFO94882.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Heart {ECO:0000313|EMBL:AFO94882.1};
RX   PubMed=24402279; DOI=10.1038/nature12826;
RG   International Elephant Shark Genome Sequencing Consortium;
RA   Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA   Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA   Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA   Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA   Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA   Wilson R.K., Brenner S., Warren W.C.;
RT   "Elephant shark genome provides unique insights into gnathostome
RT   evolution.";
RL   Nature 505:174-179(2014).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, A band
CC       {ECO:0000256|ARBA:ARBA00004161}. Cytoplasm, myofibril, sarcomere, Z
CC       line {ECO:0000256|ARBA:ARBA00004216}. Cytoplasm, perinuclear region
CC       {ECO:0000256|ARBA:ARBA00004556}.
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DR   EMBL; JW862365; AFO94882.1; -; mRNA.
DR   AlphaFoldDB; V9KAY5; -.
DR   GO; GO:0031672; C:A band; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR024660; UCS_central_dom.
DR   PANTHER; PTHR45994; FI21225P1; 1.
DR   PANTHER; PTHR45994:SF2; PROTEIN UNC-45 HOMOLOG B; 1.
DR   Pfam; PF13181; TPR_8; 2.
DR   Pfam; PF11701; UNC45-central; 1.
DR   SMART; SM00185; ARM; 3.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 2.
PE   2: Evidence at transcript level;
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Myogenesis {ECO:0000256|ARBA:ARBA00022541};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          4..37
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          75..108
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   DOMAIN          298..487
FT                   /note="UNC-45/Cro1/She4 central"
FT                   /evidence="ECO:0000259|Pfam:PF11701"
SQ   SEQUENCE   927 AA;  103806 MW;  27CB73E14643BCE6 CRC64;
     MEDPVQLKEE GNRCFQNNDH DKAIENYTKA IQLSKDKKLL GVLYRNRAAC HLKKENYVPA
     ATDASKAIDV DASDIKALFR RSQALEKLGK LDQAFKDVQR CVTIEPKNKT FQEMLRHLNT
     NIQEKLKIQF STDSRVEKMF EVLLDENTDK EKKEKAISNM IVLAREDSGA EKIFRNGGVD
     LLLRLIETKD PEMILAAIRT LSGMCSRHKA RACAIMHLVN LEKICSIMAL DHEEIALSTC
     NLLQTILETF SGEDMKDPRG KEEAMLLDTT RDEKMIIARL LEMLVNKNVS GHGRDQALNL
     LIRNVPRKNL DTKDNTRSLD AVDMGLKKIL KVAGQIPELP NCLPLTQNTC LTASILLNNI
     YCDLRCDEER ATFRTICENY VTSKFDPHNM EKNLNAIQTT SALLQGPFDV GNSILGMPGV
     MEMMVALCSS EREIDQLVAV EALIHAASKA SRANFIISNG ITLLKNMYKQ STIEKIKIRA
     LVGLCKLGSA GGTDYGLRQF SEGSTEKLAK QCRKWLCNPN IDNTTRKWAV EGMAYLTLDA
     DVKDDFVTDE ASMQAMFDLS KTADKTILYS VASILVNCTN SYDIKEKIPE LVQLAKLTKQ
     HVPEDHPKDK KDFVMKRVQR LIKAGVVSAL AVMLKADSAI LTDETKELMA RVFLALAEDV
     RDRGTIVAQG GGKTLLPLAL QGTDVGKIKA SHALAKIAAT SNPDIAFPGE RIYEVVRPLV
     TLLNMDRDGL QNYEALMGLT NLAGKTDKLR QKIIKENAMP DIENYMFEDH DQIRLAATEC
     MCNMVICKEA QERFVPEGND RMKLLVLLCG EDDVKLQRAA AGAIAMLTAS RKELCFRMTT
     STTQWLEILQ RLCLHDNVEL RHRGLVIANN LMIADKELGK LLIESELLEI LTVISKLENN
     PKRQHCINVA RECLGKAMDY GFIKPLS
//