ID   V9KD85_CALMI            Unreviewed;       948 AA.
AC   V9KD85;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Protein flightless-1-like protein {ECO:0000313|EMBL:AFO96205.1};
DE   Flags: Fragment;
OS   Callorhinchus milii (Ghost shark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX   NCBI_TaxID=7868 {ECO:0000313|EMBL:AFO96205.1};
RN   [1] {ECO:0000313|EMBL:AFO96205.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver {ECO:0000313|EMBL:AFO96205.1};
RX   PubMed=24402279; DOI=10.1038/nature12826;
RG   International Elephant Shark Genome Sequencing Consortium;
RA   Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA   Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA   Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA   Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA   Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA   Wilson R.K., Brenner S., Warren W.C.;
RT   "Elephant shark genome provides unique insights into gnathostome
RT   evolution.";
RL   Nature 505:174-179(2014).
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DR   EMBL; JW863688; AFO96205.1; -; mRNA.
DR   AlphaFoldDB; V9KD85; -.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   CDD; cd11280; gelsolin_like; 2.
DR   CDD; cd11290; gelsolin_S1_like; 1.
DR   CDD; cd11292; gelsolin_S3_like; 1.
DR   CDD; cd11288; gelsolin_S5_like; 1.
DR   CDD; cd11291; gelsolin_S6_like; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 3.40.20.10; Severin; 6.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR007123; Gelsolin-like_dom.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007122; Villin/Gelsolin.
DR   PANTHER; PTHR11977:SF139; PROTEIN FLIGHTLESS-1 HOMOLOG; 1.
DR   PANTHER; PTHR11977; VILLIN; 1.
DR   Pfam; PF00626; Gelsolin; 4.
DR   PRINTS; PR00597; GELSOLIN.
DR   SMART; SM00262; GEL; 6.
DR   SUPFAM; SSF55753; Actin depolymerizing proteins; 6.
DR   SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203}.
FT   DOMAIN          202..278
FT                   /note="Gelsolin-like"
FT                   /evidence="ECO:0000259|Pfam:PF00626"
FT   DOMAIN          318..391
FT                   /note="Gelsolin-like"
FT                   /evidence="ECO:0000259|Pfam:PF00626"
FT   DOMAIN          445..519
FT                   /note="Gelsolin-like"
FT                   /evidence="ECO:0000259|Pfam:PF00626"
FT   DOMAIN          857..933
FT                   /note="Gelsolin-like"
FT                   /evidence="ECO:0000259|Pfam:PF00626"
FT   REGION          111..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..154
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFO96205.1"
SQ   SEQUENCE   948 AA;  109370 MW;  51BF4B101FAB693A CRC64;
     RIGKLASLEE FMAANNNLEL IPESLCRCGK LKKLVLNKNR LVTLPEAVHF LTNLEILDVR
     ENPSLVMPPK PVDKTSEFYN IDFSLQNQLR LAGASPAVVA AAAGASGARD PVARKMRLRR
     RKDSSQDDQA KQVLKGMSDV AEEKNKNPQD PGELKYTDLK TRRWDQGLEK PHLNYSEFFT
     EDVGQIPGLT VWHIENFIPT MIDEAFHGKF YEADCYIVLK TSLDENGSFN WQIFYWIGQE
     ATMDKKACAA IHAVNLRNFL GAQCRTIREE MGDESEEFST VFDNYISYIE GGTASGFYTV
     EETQYITRLF RCYNKSNIKL ESVPLKASSL DPRFVFLLDH GLNIYVWRGC KATLSASTKA
     RLFAEKINKN ERKGNAEILQ LMQRQEPPEF WESLGGQPEE IKCHVPDDFK AMRPKLYKVG
     LGLGYLELPQ INYKLSVEHK VKPKIDLVPD LRLVQSLLDT KSVYILDCWS DVFIWIGRKS
     PRLVRAAALK LGQELCGMLH RPKHAIVVRN LEGSECQVFK SKFKNWDDVL KVDYTRNAET
     VLKREGLMGK VKKDAENKDQ IKADLTALFL PRQPAMLLAE AEQLTEEWNE DLDGMEGFVL
     EGKKFARLPE EDFGHFYTQD CYVFLCRYWV PVEYEDEQKD KDKMEEEGEQ EEKQQEEDFQ
     CVVYFWQGRE ASNMGWLTFT FSLQKKFESL FPGKLEVVRM TQQQENLKFL SHFKRKFVIH
     KGKRKALENS LQPSLYHIRT NGSALCSRCI QVHTEASLLN SEFCYILKVP FESTDNQGIV
     YSWVGRAADP DEAKLVEDIM NSMFVETYSK QVINEGEEPE NFFWVGIGGE KPYDEDAEYM
     KYSRLFRCSN EKGYFSVSEK CSDFCQDDLA DDDIMLLDNG KEVYMWVGTQ TSQVEIKLSL
     KACQVYIQHM RAKDSQHPRK LRLVRKGNEP HNFTRCFHAW SAFRKPPA
//