ID V9KDD0_CALMI Unreviewed; 682 AA.
AC V9KDD0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Death-associated protein kinase 1 {ECO:0000313|EMBL:AFO95934.1};
DE Flags: Fragment;
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|EMBL:AFO95934.1};
RN [1] {ECO:0000313|EMBL:AFO95934.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Kidney {ECO:0000313|EMBL:AFO95934.1};
RX PubMed=24402279; DOI=10.1038/nature12826;
RG International Elephant Shark Genome Sequencing Consortium;
RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA Wilson R.K., Brenner S., Warren W.C.;
RT "Elephant shark genome provides unique insights into gnathostome
RT evolution.";
RL Nature 505:174-179(2014).
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DR EMBL; JW863417; AFO95934.1; -; mRNA.
DR AlphaFoldDB; V9KDD0; -.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0070976; F:TIR domain binding; IEA:InterPro.
DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR CDD; cd08782; Death_DAPK1; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR017281; Myelin_different_resp_MyD88.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020859; ROC_dom.
DR PANTHER; PTHR15079; MYD88; 1.
DR PANTHER; PTHR15079:SF10; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00531; Death; 1.
DR SMART; SM00005; DEATH; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51424; ROC; 1.
PE 2: Evidence at transcript level;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Kinase {ECO:0000313|EMBL:AFO95934.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000313|EMBL:AFO95934.1}.
FT DOMAIN 1..205
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
FT DOMAIN 562..648
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFO95934.1"
SQ SEQUENCE 682 AA; 76986 MW; 3B70F48A8F3642FE CRC64;
AGCENVSVRC RSMMFEPSLT KGMLEAFVSP SHNNHSTIDD QSTKAVDIQH ANVNGVGDFN
IWEFSGNPVY YCCYDYFAVN DPTAVHMVLF SLEEPYETQL NQVTFWLNFL KSLIPAGEPI
AFGGKLKNPL QVVLVATHAD IVNCPRTFGG EFAYDKDLSL LKEIRSRFGN DMHISDRLFV
LDVGASGSKD MKLLRTYLLE LRYWIISACP PMTFLCEKII SILPSWRKRN GPNQFMSWQQ
FVYDVQDRIN PLVSEEDLRE LAQQLHSMGE INILQSETIQ DVVLLDPRWL CTYVLGRLLS
NENQKALHHY RGRYTIDDIQ HLVLENDVEE LLQILDAMDI CARDLTSGSM VDIPALIKVD
SLHRSWTEEE DEMLVYGGVR FVPVEYHTPF PCGIFHKVQV NLCRWIHQQN SEGEMDIRLW
TNGSKISNKG TEVLVLLVNH GQGVEVQVRG PEVEKIRCYM FLDSICSVID NLMATTLPGL
LAVKHYLSPQ QLRERSEPIM VYQPRDFFRA QVHRETSLTN AMGGYKESFS SILCFGCHDI
YSQGSLGMDI PVSELNNLAR RKLIRLLDPP DPMGKDWCLL ATNLGLVDLV AKLNVQNGTS
REGKLPASPM DTLLNEWAAL PESNVGLLMS KLRGLGRRDA ADFLLKASAI FKVNLDTNGH
ETYASICNGG TSYNSISSVV SR
//
