ID V9KF37_CALMI Unreviewed; 743 AA.
AC V9KF37;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=TPX2 microtubule nucleation factor {ECO:0000313|Ensembl:ENSCMIP00000035452.1};
DE SubName: Full=Targeting protein for Xklp2 {ECO:0000313|EMBL:AFO96889.1};
GN Name=tpx2 {ECO:0000313|Ensembl:ENSCMIP00000035452.1};
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|EMBL:AFO96889.1};
RN [1] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17185593; DOI=10.1126/science.1130708;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Ancient noncoding elements conserved in the human genome.";
RL Science 314:1892-1892(2006).
RN [2] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17407382;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Survey sequencing and comparative analysis of the elephant shark
RT (Callorhinchus milii) genome.";
RL PLoS Biol. 5:E101-E101(2007).
RN [3] {ECO:0000313|EMBL:AFO96889.1, ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Intestine {ECO:0000313|EMBL:AFO96889.1};
RX PubMed=24402279; DOI=10.1038/nature12826;
RG International Elephant Shark Genome Sequencing Consortium;
RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA Wilson R.K., Brenner S., Warren W.C.;
RT "Elephant shark genome provides unique insights into gnathostome
RT evolution.";
RL Nature 505:174-179(2014).
RN [4] {ECO:0000313|Ensembl:ENSCMIP00000035452.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000256|ARBA:ARBA00004647}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TPX2 family.
CC {ECO:0000256|ARBA:ARBA00005885}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JW864372; AFO96889.1; -; mRNA.
DR RefSeq; XP_007903342.1; XM_007905151.1.
DR STRING; 7868.ENSCMIP00000035452; -.
DR Ensembl; ENSCMIT00000035979.1; ENSCMIP00000035452.1; ENSCMIG00000014990.1.
DR GeneID; 103186249; -.
DR KEGG; cmk:103186249; -.
DR CTD; 22974; -.
DR GeneTree; ENSGT00390000009842; -.
DR OrthoDB; 3131538at2759; -.
DR Proteomes; UP000314986; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0060236; P:regulation of mitotic spindle organization; IEA:InterPro.
DR InterPro; IPR015128; Aurora-A-bd.
DR InterPro; IPR027329; TPX2_C.
DR InterPro; IPR027330; TPX2_central_dom.
DR InterPro; IPR009675; TPX2_fam.
DR PANTHER; PTHR14326; TARGETING PROTEIN FOR XKLP2; 1.
DR PANTHER; PTHR14326:SF44; TARGETING PROTEIN FOR XKLP2; 1.
DR Pfam; PF09041; Aurora-A_bind; 1.
DR Pfam; PF06886; TPX2; 2.
DR Pfam; PF12214; TPX2_importin; 1.
PE 2: Evidence at transcript level;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000314986}.
FT DOMAIN 3..36
FT /note="Aurora-A binding"
FT /evidence="ECO:0000259|Pfam:PF09041"
FT DOMAIN 355..483
FT /note="TPX2 central"
FT /evidence="ECO:0000259|Pfam:PF12214"
FT DOMAIN 536..584
FT /note="TPX2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06886"
FT DOMAIN 656..730
FT /note="TPX2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06886"
FT REGION 108..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..722
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 85280 MW; 34FD078687FEDF11 CRC64;
MAAWNYDAPT HIDFCNLDDQ DDLHVDYWFD KQAENEVGIN QATPPAESKN LVVQLPHVPC
KSSLVQAAQS PKGQLLPKEG ESAEEQIDGT VGSVPSNVVT SLSVWRTTSA APARGTPVRR
SARRPPGQVK KQLAELRADR RFQDPATGAP VSKKAKLNPK AKTSVSRVGS LRQSQSSAQT
RQAMPSTPTV LKRQQHMGAK GKSTEELEME KISQFQKEFA EQRKLNEETL KAAICGTSQH
SKLMRIPATK PMDIQFHTDK RIKAHGETQV YKEVNFTNEL RKHPQSPMRA LKGSTVPKPF
NLSCGSKRKH TDMESKAYVS VAQQVEEFQR RTPSRYHLRS KQLVEEGPHR VPMKMKLTKP
LTPLLTTKGR AREATCKSTA EIEAEEVEKI QSYRFKAQEL NPRILEGGPI VPKKPPVKEP
TEPIGFRLET DNRIRKREEN RKPEDQEQYL FHPRPCPIRI LEDVVGVPEK RKLPLTVPHS
PVFAVKSRVR IPLKEEQEEK LVKQIKINTM PHCAVPFKPK PLEEKNVEIQ PFSFEARDKE
RQTLKEKKLQ EIRKEMAEVP TFKAQPLPDF DLAQLPEKVV KSPTKLQPFH LRIEERGVVR
AERWTQMMKE ELRQQKEAAC FKANPSSAIY REPFVPKKAE RSLTEKLSAS VVQESFELAT
EKRAKERMEF EKYKADKEVM REQAEQEKQN RKEEQERKEI AQLRHDQIHK ANPVRHYKKV
EIQPSEQQLT VPTTPNFSDR FRL
//