ID   V9KFA7_CALMI            Unreviewed;       915 AA.
AC   V9KFA7;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Cingulin {ECO:0000256|ARBA:ARBA00044075};
DE   Flags: Fragment;
OS   Callorhinchus milii (Ghost shark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX   NCBI_TaxID=7868 {ECO:0000313|EMBL:AFO96543.1};
RN   [1] {ECO:0000313|EMBL:AFO96543.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Ovary {ECO:0000313|EMBL:AFO96543.1};
RX   PubMed=24402279; DOI=10.1038/nature12826;
RG   International Elephant Shark Genome Sequencing Consortium;
RA   Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA   Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA   Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA   Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA   Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA   Wilson R.K., Brenner S., Warren W.C.;
RT   "Elephant shark genome provides unique insights into gnathostome
RT   evolution.";
RL   Nature 505:174-179(2014).
CC   -!- FUNCTION: Probably plays a role in the formation and regulation of the
CC       tight junction (TJ) paracellular permeability barrier.
CC       {ECO:0000256|ARBA:ARBA00043864}.
CC   -!- SIMILARITY: Belongs to the cingulin family.
CC       {ECO:0000256|ARBA:ARBA00038467}.
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DR   EMBL; JW864026; AFO96543.1; -; mRNA.
DR   AlphaFoldDB; V9KFA7; -.
DR   GO; GO:0016459; C:myosin complex; IEA:InterPro.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   InterPro; IPR002928; Myosin_tail.
DR   PANTHER; PTHR46349:SF4; CINGULIN; 1.
DR   PANTHER; PTHR46349; CINGULIN-LIKE PROTEIN 1-RELATED; 1.
DR   Pfam; PF01576; Myosin_tail_1; 2.
DR   SUPFAM; SSF90257; Myosin rod fragments; 1.
DR   SUPFAM; SSF57997; Tropomyosin; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}.
FT   DOMAIN          245..559
FT                   /note="Myosin tail"
FT                   /evidence="ECO:0000259|Pfam:PF01576"
FT   DOMAIN          486..894
FT                   /note="Myosin tail"
FT                   /evidence="ECO:0000259|Pfam:PF01576"
FT   REGION          1..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          728..757
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          787..821
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          253..364
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        69..107
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        788..821
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFO96543.1"
FT   NON_TER         915
FT                   /evidence="ECO:0000313|EMBL:AFO96543.1"
SQ   SEQUENCE   915 AA;  105606 MW;  7D0AA8E82C87B8EA CRC64;
     GGRGRGPAKP HSHHLPAAPK PLAKVSSTAD MSVTPLDPTV IDTKPLSSVD SLISKFDTRG
     GPLRGRPVRR SRLSSDEKRR SQSLDNQSRE RQVHRETVSD QRPLEKVAGR KYYGSSEALD
     VLPASSTLPV KQSVTEHLPL HTAQSGKPHH RVSEGLGLMA ASPHTQQHHH ITATATQPLA
     ERSPKREIQL KSTPDLLKDQ QEHSPTSEQR TKRLIFNILK DGTIESESSL RRKASLVFDK
     VQDAKMASVS PEVSTLSSQK NELERKVSDL QHKLDKQILS RKNVESKKSL NIAELQDLQV
     QLEENIEEKE QLKAVYQKTR KELQGIMQEL MDMKMEKETV EAEMRDLQEE MKVIHRELRN
     ARKSADDSGD SEGLLTELAR TKEELDLIAN AKQGVENILR QRERELTALK GVLKEEVSNH
     DKAMEDLREQ CQQDMDHLRK NIEQVTQTQQ SLESERQKVN STVRSLQRQL EESNEETGHW
     KEMFQKTRDE LRGIKQELLQ MKMEKEECEE ELRDMKDRYS YIQDEMDHVK KTSVDNDKLL
     TLQKELASAK KELQQLEAVK DSQESVLQRK AQDVSALQGT LSDEAARHAK ELEKVRQQSQ
     REVELLRRNF EEASKVRSSL EEDVGAAEQA RRVAESALKQ LKQDNEDFKR KFSQLDFQVG
     EYQDRIVEQE AMEGRLRDKL AKIEAERKHM EQTLGDQADQ EQELAVAKRT LESRLEESQR
     ALHRLTQDHQ ELSDRFQEET RQKDQLRRAK GDLEEQKRAL DRSLEKLQRE VEEASQQSGN
     SLVTLQSQLE EHREKSRREL SELQRQGKER AMELEKSHQS IKRLQEEIGR LKHELQQSQA
     EKESAFLDKE LLEQRLQKLE QDVDSKRRTQ EGGSRQVKVL EIARLKHELQ QSQAGRESAA
     LDKELLEQRL QKVEQ
//