ID V9KKD9_CALMI Unreviewed; 544 AA.
AC V9KKD9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 22-FEB-2023, entry version 27.
DE SubName: Full=Neuropilin (NRP) and tolloid (TLL)-like 1 {ECO:0000313|EMBL:AFO98577.1};
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|EMBL:AFO98577.1};
RN [1] {ECO:0000313|EMBL:AFO98577.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis {ECO:0000313|EMBL:AFO98577.1};
RX PubMed=24402279; DOI=10.1038/nature12826;
RG International Elephant Shark Genome Sequencing Consortium;
RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA Wilson R.K., Brenner S., Warren W.C.;
RT "Elephant shark genome provides unique insights into gnathostome
RT evolution.";
RL Nature 505:174-179(2014).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; JW866060; AFO98577.1; -; mRNA.
DR AlphaFoldDB; V9KKD9; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251:SF27; NEUROPILIN AND TOLLOID-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..544
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004778277"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..157
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 174..289
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 43..70
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 294..306
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 301..319
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 313..328
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 544 AA; 61396 MW; D47A3F794A5DFBB3 CRC64;
MVQGRRLGLL HVVSSLILLG LCVATKKDSD KTRSSERQKP VQCGSWIKNP NGGSFTSPNY
PSMYPPDQEC IYIIEAAPRQ SIELYFDEKY SIEPSWECKF DHIEVRDGPF GFSTEIGRYC
GQQIPPFITS SGRFLWIKFF ADGELESIGF LARYNFIPDP EFAHLGVLKP LPVCEFEMGG
PEGIIESLQI VQEGKANSIE AVDCKWYIQA PPKSKIYLRF LDYEMENSND CKRNFVAIYD
GSSSVEDLKA KFCSTVANDL MLGTGFGVIR MWADEGSRNS HFQMLFTSFR EPPCDANTFF
CHSNMCINDT LVCNGVQNCV YPWDENHCKE KRKASLLDQL TNTSGTIIGI TSCIVIILIV
ISVIVQIKQP RKKFIQRKPD FDQTVFQEVF EPTHYELCSL KGKGAAADLG DIVDDFENYH
KLRRSSSKCI HDHHCGSQMS SIKGSRSNLS TRDATILSEI QPQPVKPSVQ PMSRRSILVM
KHSYSQDAAD ACDIDEIEEV PTTSHRLSRN DKSVQRLLEN SMLLDDFEHA SKNFEIVDLG
HTSA
//
