ID   V9KMD1_CALMI            Unreviewed;       599 AA.
AC   V9KMD1;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Metal-response element-binding transcription factor 2-like protein {ECO:0000313|EMBL:AFO99326.1};
OS   Callorhinchus milii (Ghost shark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX   NCBI_TaxID=7868 {ECO:0000313|EMBL:AFO99326.1};
RN   [1] {ECO:0000313|EMBL:AFO99326.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Heart {ECO:0000313|EMBL:AFO99326.1};
RX   PubMed=24402279; DOI=10.1038/nature12826;
RG   International Elephant Shark Genome Sequencing Consortium;
RA   Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA   Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA   Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA   Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA   Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA   Wilson R.K., Brenner S., Warren W.C.;
RT   "Elephant shark genome provides unique insights into gnathostome
RT   evolution.";
RL   Nature 505:174-179(2014).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the Polycomblike family.
CC       {ECO:0000256|ARBA:ARBA00008084}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JW866809; AFO99326.1; -; mRNA.
DR   AlphaFoldDB; V9KMD1; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035064; F:methylated histone binding; IEA:UniProt.
DR   CDD; cd15578; PHD1_MTF2; 1.
DR   CDD; cd15580; PHD2_MTF2; 1.
DR   CDD; cd20450; Tudor_MTF2; 1.
DR   Gene3D; 2.30.30.140; -; 1.
DR   Gene3D; 3.90.980.20; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR040477; KDM4-like_Tudor.
DR   InterPro; IPR025894; Mtf2_C_dom.
DR   InterPro; IPR042014; MTF2_PHD1.
DR   InterPro; IPR042015; MTF2_PHD2.
DR   InterPro; IPR002999; Tudor.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12628:SF12; METAL-RESPONSE ELEMENT-BINDING TRANSCRIPTION FACTOR 2; 1.
DR   PANTHER; PTHR12628; POLYCOMB-LIKE TRANSCRIPTION FACTOR; 1.
DR   Pfam; PF14061; Mtf2_C; 1.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF18104; Tudor_2; 1.
DR   SMART; SM00249; PHD; 2.
DR   SMART; SM00333; TUDOR; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00146}.
FT   DOMAIN          103..158
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..532
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        450..497
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   599 AA;  68083 MW;  41708E48AE0BB56D CRC64;
     MDRDTTGAGN SSLHKRSPSR RNQKTPVSSV HLSLRDGPKG KQTVCKFEEG QDVLARWSDG
     LFYLGTVKKV NKQKESCFVI FEDSSKSWVL WKDIQTGASG SGEMVCTICQ EEYSEAPNEM
     VICDKCGQGY HQKCHIPNID SSVIASDAKW LCRQCVFATT TKRGGALKKG PNAKALQVMK
     QTLPYQLEDL QWDLGHKTNH QQCYCYCGGP GDWYLKMLQC WRCKQWFHEA CIQCLQKPML
     YGDRFYLFIC SVCNSGPEYL KRLPLRWVDI AHLSLYNLSV IHKKKYFDSE LELMTYINEN
     WDRLQPGELI DTLKTERYDH ILEALNENKC MFMSGKEIKK KKHLFGLRIR VPPIPPNTAL
     KTEESNEEVS HEFKIKGRKS SKSTVLPVSI RSSLSNGIEK KGKKKCSVDL AEQYTKLKKV
     RRFSDTTVDQ STVLDTLALD LPGPKRRLVE KTAQSSNTSD VESIGAASTA ETTSTSVSRQ
     SSLSGPRRRT RTGRSWPLTL QRLKKRRGRT STRTFQPQTS ESGNDNEEKD DCQYEGLDPE
     IIDINDQDMH LNHLKSSITN YFGAAGRLAC GEKYRILARR VTLDGKVQYL VEWEGITAS
//