ID   V9KQL9_CALMI            Unreviewed;       547 AA.
AC   V9KQL9;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=Neurofilament light polypeptide {ECO:0000256|ARBA:ARBA00019275};
DE   AltName: Full=Neurofilament triplet L protein {ECO:0000256|ARBA:ARBA00033132};
OS   Callorhinchus milii (Ghost shark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX   NCBI_TaxID=7868 {ECO:0000313|EMBL:AFP00596.1};
RN   [1] {ECO:0000313|EMBL:AFP00596.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:AFP00596.1};
RX   PubMed=24402279; DOI=10.1038/nature12826;
RG   International Elephant Shark Genome Sequencing Consortium;
RA   Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA   Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA   Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA   Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA   Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA   Wilson R.K., Brenner S., Warren W.C.;
RT   "Elephant shark genome provides unique insights into gnathostome
RT   evolution.";
RL   Nature 505:174-179(2014).
CC   -!- SUBCELLULAR LOCATION: Cell projection, axon
CC       {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; JW868078; AFP00596.1; -; mRNA.
DR   RefSeq; XP_007883808.1; XM_007885617.1.
DR   AlphaFoldDB; V9KQL9; -.
DR   GeneID; 103172926; -.
DR   KEGG; cmk:103172926; -.
DR   OrthoDB; 4640531at2759; -.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR006821; Intermed_filament_DNA-bd.
DR   PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR   PANTHER; PTHR45652:SF8; NEUROFILAMENT LIGHT POLYPEPTIDE; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF04732; Filament_head; 1.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}.
FT   DOMAIN          89..399
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          463..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          93..225
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          318..370
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        479..532
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        533..547
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   547 AA;  61719 MW;  572714C808460DC5 CRC64;
     MSTASYDSYF HSQRKRYGDS PVSRVYGGIQ HSRSSIGSSI KPIRSTYSVQ SFSGRKGHAS
     PSMISALDTF DLSQASAVSS EFRTVRTQEK AQLQELNDRF ASFIEKVHEL EQQNKVLEAE
     LSILRQKHGS PSRLKAIYEQ EVRELRLALE EAKQDRQAAQ GERSQLEEAL RSLQVRYEEE
     VLAREDAEAR LLEARKGADE AALGRAEVEK KIDCLVDEIA FLKKVHEEEI VELQAQIQYA
     HLSVEMEVAK PDLSSALREI RAQYEKVAAK NMQSAEEWYS SRFAVMTETA HKDNDAMKMA
     REDVVECRRQ VKAKSLEIDA VRGMNEALER QLQELDEKQN GEIIGLQDNI NQLENELRTT
     KNEMGRYLKE YQDLLNVKMA LDIEIAAYRK LLEGEETRIT YSNVGSMMSG YSQTHSTPMF
     GRSTYSLQSS SFLMPSRLVP YGSYSGSQAE EELAQVEETI EQTEAEEAQM QPPTDQAEET
     EGEGAEGEGS EEGGGEEEEE EEAGGEEEGG EEESEEKDEG VEGDDEQQEE ESKNGAEETS
     KKEQEKK
//