ID V9KTP5_CALMI Unreviewed; 337 AA.
AC V9KTP5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Nuclear migration protein nudC {ECO:0000256|ARBA:ARBA00017641};
DE AltName: Full=Nuclear distribution protein C homolog {ECO:0000256|ARBA:ARBA00030427};
GN Name=nudc {ECO:0000313|Ensembl:ENSCMIP00000045570.1};
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|EMBL:AFP01870.1};
RN [1] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17185593; DOI=10.1126/science.1130708;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Ancient noncoding elements conserved in the human genome.";
RL Science 314:1892-1892(2006).
RN [2] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17407382;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Survey sequencing and comparative analysis of the elephant shark
RT (Callorhinchus milii) genome.";
RL PLoS Biol. 5:E101-E101(2007).
RN [3] {ECO:0000313|EMBL:AFP01870.1, ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:AFP01870.1};
RX PubMed=24402279; DOI=10.1038/nature12826;
RG International Elephant Shark Genome Sequencing Consortium;
RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA Wilson R.K., Brenner S., Warren W.C.;
RT "Elephant shark genome provides unique insights into gnathostome
RT evolution.";
RL Nature 505:174-179(2014).
RN [4] {ECO:0000313|Ensembl:ENSCMIP00000045570.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Midbody
CC {ECO:0000256|ARBA:ARBA00004214}.
CC -!- SIMILARITY: Belongs to the nudC family.
CC {ECO:0000256|ARBA:ARBA00010513}.
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DR EMBL; JW869352; AFP01870.1; -; mRNA.
DR RefSeq; XP_007893129.1; XM_007894938.1.
DR RefSeq; XP_007893131.1; XM_007894940.1.
DR STRING; 7868.ENSCMIP00000045570; -.
DR Ensembl; ENSCMIT00000046223.1; ENSCMIP00000045570.1; ENSCMIG00000018794.1.
DR GeneID; 103179574; -.
DR KEGG; cmk:103179574; -.
DR CTD; 10726; -.
DR GeneTree; ENSGT00940000155361; -.
DR OMA; QDGPRIQ; -.
DR OrthoDB; 141208at2759; -.
DR Proteomes; UP000314986; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd06492; p23_mNUDC_like; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR032572; NuDC.
DR InterPro; IPR037898; NudC_fam.
DR InterPro; IPR025934; NudC_N_dom.
DR PANTHER; PTHR12356:SF3; NUCLEAR MIGRATION PROTEIN NUDC; 1.
DR PANTHER; PTHR12356; NUCLEAR MOVEMENT PROTEIN NUDC; 1.
DR Pfam; PF04969; CS; 1.
DR Pfam; PF16273; NuDC; 1.
DR Pfam; PF14050; Nudc_N; 1.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR PROSITE; PS51203; CS; 1.
PE 2: Evidence at transcript level;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000314986}.
FT DOMAIN 173..264
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT REGION 62..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 337 AA; 38799 MW; F2AF7CD38A07AD52 CRC64;
MGDSASEDRF DGILLAMAQQ HEGGVHQLVD TFFSFLRRKT DFFTGGETGA AEKLVTETFK
RHHKSATEAQ KEKQVKQEKE KKENAERAAR LAEEKRKVEP ELKQPKIQEL TEEEAEKLQR
EIDQKKQDVQ NAAETNGEES PAIPEPKQTE SDSDGEEDEK DKGKLKPNSG NGADLPNYRW
TQSLSEVDLL IPFQVNFRLK SRDLIVEIQR RHLKVGLKGH SLVLDGELYN DVKVEESSWL
LEDGKSINVH LEKINKMEWW NKIVTTDPEI NTKKVNPENS KLSDLDSETR SMVEKMMYDQ
RQKAMGLPTS EEQKKQDILK KFMEQHPEMD FSKAKFS
//
