ID V9KYF7_CALMI Unreviewed; 387 AA.
AC V9KYF7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=SRY (Sex determining region Y)-box 18 {ECO:0000313|EMBL:AFP03711.1};
DE SubName: Full=SRY-box transcription factor 18 {ECO:0000313|Ensembl:ENSCMIP00000041101.1};
GN Name=SOX18 {ECO:0000313|Ensembl:ENSCMIP00000041101.1};
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|EMBL:AFP03711.1};
RN [1] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17185593; DOI=10.1126/science.1130708;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Ancient noncoding elements conserved in the human genome.";
RL Science 314:1892-1892(2006).
RN [2] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17407382;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Survey sequencing and comparative analysis of the elephant shark
RT (Callorhinchus milii) genome.";
RL PLoS Biol. 5:E101-E101(2007).
RN [3] {ECO:0000313|EMBL:AFP03711.1, ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:AFP03711.1};
RX PubMed=24402279; DOI=10.1038/nature12826;
RG International Elephant Shark Genome Sequencing Consortium;
RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA Wilson R.K., Brenner S., Warren W.C.;
RT "Elephant shark genome provides unique insights into gnathostome
RT evolution.";
RL Nature 505:174-179(2014).
RN [4] {ECO:0000313|Ensembl:ENSCMIP00000041101.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; JW871193; AFP03711.1; -; mRNA.
DR RefSeq; XP_007883198.1; XM_007885007.1.
DR STRING; 7868.ENSCMIP00000041101; -.
DR Ensembl; ENSCMIT00000041681.1; ENSCMIP00000041101.1; ENSCMIG00000017133.1.
DR GeneID; 103172200; -.
DR KEGG; cmk:103172200; -.
DR CTD; 54345; -.
DR GeneTree; ENSGT00940000162709; -.
DR OMA; FSMSHHG; -.
DR OrthoDB; 2902801at2759; -.
DR Proteomes; UP000314986; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22048; HMG-box_SoxF_SOX18; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR033392; Sox7/17/18_central.
DR InterPro; IPR021934; Sox_C.
DR PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR10270:SF204; TRANSCRIPTION FACTOR SOX-18; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12067; Sox17_18_mid; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS51516; SOX_C; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000314986}.
FT DOMAIN 60..128
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DOMAIN 263..386
FT /note="Sox C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51516"
FT DNA_BIND 60..128
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 15..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 43110 MW; F53D3B8D00848582 CRC64;
MNISEAGYCG VEDSQAGSCG LDAATPSPWA QSGSPASQSG SEAAQLTAKP EGRSELESRI
RRPMNAFMVW AKDERKRLAL QNPDLHNAVL SKMLGQAWKS LPTDEKRPFV EEAERLRVQH
LHDHPNYKYR PRRKKQSKKI KRIEGNLLAH HGLSQSHGSA LRNSPAICAE SFALNAHEGR
HQLPALARYH DLHVMGSDLE SYGLPTPEMS PLEVLDTDPV FFPAQEDCGV SYTHFQLHPD
YIQDKPRTLT HPSTGEMTPY SDQMPGGMPE LLRNPPNLYY DQLCPGAQGS GMSSHLGQLS
PPPEARPVDC SVDQHLGHQV ELWTDVDRNE FDQYLNLTRT RPDCSSQHFH VSLSKRHPRG
MSCEESSFIS ALIDASNAVY YNPCITG
//
