ID V9L3I3_CALMI Unreviewed; 335 AA.
AC V9L3I3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 22-FEB-2023, entry version 24.
DE SubName: Full=Neutrophil cytosol factor 4 {ECO:0000313|EMBL:AFP05595.1};
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|EMBL:AFP05595.1};
RN [1] {ECO:0000313|EMBL:AFP05595.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Spleen {ECO:0000313|EMBL:AFP05595.1};
RX PubMed=24402279; DOI=10.1038/nature12826;
RG International Elephant Shark Genome Sequencing Consortium;
RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA Wilson R.K., Brenner S., Warren W.C.;
RT "Elephant shark genome provides unique insights into gnathostome
RT evolution.";
RL Nature 505:174-179(2014).
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DR EMBL; JW873077; AFP05595.1; -; mRNA.
DR AlphaFoldDB; V9L3I3; -.
DR OrthoDB; 2997622at2759; -.
DR GO; GO:0043020; C:NADPH oxidase complex; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IEA:InterPro.
DR GO; GO:0006909; P:phagocytosis; IEA:InterPro.
DR GO; GO:0045730; P:respiratory burst; IEA:InterPro.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000919; p40phox.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15706:SF20; NEUTROPHIL CYTOSOL FACTOR 4; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00497; P40PHOX.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 17..133
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 162..221
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 233..325
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
SQ SEQUENCE 335 AA; 38786 MW; 8F3EFAE01DDEA9C2 CRC64;
MQRQLRVESD YDQLPDNVPI SAHIADAEEH KGFSRHFLFV IQVKLKGGSR HLIFRRYREF
HNLQLSLMDT FPDGQRQLLP TLPGKIIVGN KQEIAEKRIP ELNLYMKRLL CLPSWIVLHE
YIRMFFYQTK YDSEQVPRSL RRLRPATRKV ITKPKLVVTD RSQGPRAEAL YDFSGDNVLD
LCFVTGDLIF LLRRVNADWL EGSVRDETGI FPRSFVKMVK DLPYGSADGD HTVNYLRCVY
HSPEGVTIRD IAVNERLSVK PTYKDLSSLV CAEFGHQDLA VNYRDAEGDL VRMTDDMDVE
LMVEEAQGHS LGQDYFPWQL HVTSHTDLSL YNTQP
//
