ID V9LMM9_HCMV Unreviewed; 373 AA.
AC V9LMM9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Envelope glycoprotein M {ECO:0000313|EMBL:AFR54917.1};
GN Name=UL100 {ECO:0000313|EMBL:AFR54917.1};
OS Human cytomegalovirus (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus;
OC Cytomegalovirus humanbeta5.
OX NCBI_TaxID=10359 {ECO:0000313|EMBL:AFR54917.1, ECO:0000313|Proteomes:UP000137409};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AFR54917.1, ECO:0000313|Proteomes:UP000137409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HAN1 {ECO:0000313|EMBL:AFR54917.1};
RA Davison A.J.;
RT "Human cytomegalovirus RL11 gene family: variation, recombination and
RT transcription.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000096064, ECO:0000313|Proteomes:UP000145367}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BE/29/2010 {ECO:0000313|EMBL:AKI21191.1}, and CZ/2/2013
RC {ECO:0000313|EMBL:AKI12826.1};
RX PubMed=25972543;
RA Sijmons S., Thys K., Mbong Ngwese M., Van Damme E., Dvorak J.,
RA Van Loock M., Li G., Tachezy R., Busson L., Aerssens J., Van Ranst M.,
RA Maes P.;
RT "High-throughput analysis of human cytomegalovirus genome diversity
RT highlights the widespread occurrence of gene-disrupting mutations and
RT pervasive recombination.";
RL J. Virol. 89:7673-7695(2015).
CC -!- FUNCTION: Envelope glycoprotein important for virion assembly and
CC egress. Plays a role in the correct incorporation of gH-gL into virion
CC membrane. Directs the glycoprotein N (gN) to the host trans-Golgi
CC network. {ECO:0000256|ARBA:ARBA00003017}.
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DR EMBL; JX512199; AFR54917.1; -; Genomic_DNA.
DR EMBL; KP745664; AKI12826.1; -; Genomic_DNA.
DR EMBL; KP745714; AKI21191.1; -; Genomic_DNA.
DR Proteomes; UP000096064; Genome.
DR Proteomes; UP000137409; Genome.
DR Proteomes; UP000145367; Genome.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0044201; C:host cell nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR HAMAP; MF_04035; HSV_GM; 1.
DR InterPro; IPR000785; Herpes_glycop_M.
DR Pfam; PF01528; Herpes_glycop; 1.
DR PRINTS; PR00333; HSVINTEGRLMP.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AFR54917.1};
KW Virion {ECO:0000313|EMBL:AFR54917.1}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 347..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 373 AA; 42833 MW; 74AC5D6A0F50C9D8 CRC64;
MAPSHVDKVN TRTWSASIVF MVLTFVNVSV HLVLSNFPHL GYPCVYYHVV DFERLNMSAY
NVMHLHTPML FLDSVQLVCY AVFMQLVFLA VTIYYLVCWI KISMRKDKGM SLNQSTRDIS
YMGDSLTAFL FILSMDTFQL FTLTMSFRLP SMIAFMAAVH FFCLTIFNVS MVTQYRSFKR
SLFFFSRLHP KLKGTVQFRT LIVNLVEMAL GFNTTVVAMA LCYGFGNNFF VRTGHMVLAV
FVVYAIISII YFLLIEAIFF QYVKVQFGYH LGAFFGLCGL IYPIVQYGAF TIGDDYRTGI
SWSFGMLFFI WAMFTTCRAV RYFRGRGSGS VKYQALATAS GEEVAALSHH DSLESRRLRE
EEDDDDDEDF EDA
//
