ID V9Q3N8_9NEOB Unreviewed; 233 AA.
AC V9Q3N8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=bdnf-b {ECO:0000313|EMBL:AHC08314.1};
OS Vitreorana castroviejoi.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Centrolenidae; Centroleninae;
OC Cochranellini; Vitreorana.
OX NCBI_TaxID=526139 {ECO:0000313|EMBL:AHC08314.1};
RN [1] {ECO:0000313|EMBL:AHC08314.1}
RP NUCLEOTIDE SEQUENCE.
RA Castroviejo-Fisher S., Guayasamin J.M., Gonzalez-Voyer A., Vila C.;
RT "Neotropical diversification seen through glassfrogs.";
RL J. Biogeogr. 41:66-80(2014).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; KF534351; AHC08314.1; -; Genomic_DNA.
DR AlphaFoldDB; V9Q3N8; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF3; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 125..232
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 133..200
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 178..229
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 188..231
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AHC08314.1"
FT NON_TER 233
FT /evidence="ECO:0000313|EMBL:AHC08314.1"
SQ SEQUENCE 233 AA; 26250 MW; 26FE384EB4F0FA54 CRC64;
ISYFSCMKAA PMKEASVRGQ SGLAYPGLRT HGTLESIGGP MGSSRGGGLP SLTDTFEHVI
EELLEEEQNI RQSEENKDSD MYSSRVMLST QVPLEPPLLF LLEEYKNYLD AANMSMRVRR
HSDPARRGEL SVCDSISEWV TAADKKTAID MAGQTVTVLE KVPVPKGQLK QYFYETKCNP
MGYMKEGCRG IDKRYWNSQC RTTQSYVRAL TMDSKKKVGW RFIRIDTSCV CTL
//