ID V9XBA3_9NOCA Unreviewed; 1946 AA.
AC V9XBA3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Peptide synthetase {ECO:0000313|EMBL:AHD20731.1};
GN ORFNames=Y013_08660 {ECO:0000313|EMBL:AHD20731.1};
OS Rhodococcus pyridinivorans SB3094.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=1435356 {ECO:0000313|EMBL:AHD20731.1, ECO:0000313|Proteomes:UP000018781};
RN [1] {ECO:0000313|EMBL:AHD20731.1, ECO:0000313|Proteomes:UP000018781}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB3094 {ECO:0000313|EMBL:AHD20731.1,
RC ECO:0000313|Proteomes:UP000018781};
RX PubMed=24874690;
RA Dueholm M.S., Albertsen M., D'Imperio S., Tale V.P., Lewis D.,
RA Nielsen P.H., Nielsen J.L.;
RT "Complete Genome of Rhodococcus pyridinivorans SB3094, a Methyl-Ethyl-
RT Ketone-Degrading Bacterium Used for Bioaugmentation.";
RL Genome Announc. 2:e00525-14(2014).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP006996; AHD20731.1; -; Genomic_DNA.
DR RefSeq; WP_024101633.1; NC_023150.1.
DR GeneID; 29938324; -.
DR KEGG; rpy:Y013_08660; -.
DR PATRIC; fig|1435356.3.peg.1736; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_0_9_11; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000018781; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 537..612
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1597..1673
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1946 AA; 207647 MW; 474B9A03C05742F1 CRC64;
MTTNAMDFDS AHSDEGSVSG IRTSGSPRRL RRSAPTASLP HLLAVAVERN PDGIAVVSES
GALTYRELDA GSSRLARLLI SRGIGPEDCV AQFLTRSLES VLATWAVAKT GAAFVPVDPT
YPADRIAYML DDSGAGLVLT TEEHADSLPG ELPALVLDSA EVRDESAGMS SEPVFFDERR
GVVRAENAAY VIYTSGSTGR PKGVVVTHSG LANFCAEQVD RYGLSPQSRT LHFASPSFDA
SVLELLLAVG ASSTMVVAPL TVFGGSEFAD VVRKHGVTHA FVTPAALASV DPAGLEVLGT
VAVGGEACPP ELVTRWAPGR RFHNVYGPTE TTIVSNISEP LAAGDRVTIG PPIGNVTETV
LDSRLHPVPV GVAGELYTAG PGVARGYLGR PGLTAARFVA APGGARMYRT GDVVRGPETP
SSGIVYVGRN DFQVKVRGFR IELGEIDAAL ASHPGVDFAL TVGRETPAGE TQLVSYVHGT
DGPLDPGSLV EHVAGVLPTY MVPAAVVPLD RIPLTPSGKV DRAALPQVGA TVAEFRAPVT
ASEKAVADVF ADVLGVDRVG LDDDFFDLGG NSLLATSVVG RIRARLGVTV RAAALFDEPT
VAALARHLDA AGSDRAVPLV AGPRPAHLPL SYAQQRMWFL NRLDPESALY NIPLAVRLTG
GLDVDAMRAA FADLVERHET LRTVYPEIDG VGEQRILEPG ARVVDVPVEQ VPAGELPEHL
ARVAGRGFDV TAEVPVRAHL FATAPDEHVL VLVLHHIAGD GTSLAPLVRD LVTAYTARVG
GHAPDWAPLP VQYADYTLWQ REVLGTDDDP ESIAGRQLAY WTGALAGVPE HLDLATDHVR
PAILGAGGGA VRIELEDDVH EAITVLARRA GTTPFMVVHA ALAALLARLS NTHDVVIGTP
VAGRSAPELD GVVGMFVNML ALRTEVDLGG TFADLLEQAR TVDIDAFDHA DIPFERLVEV
LDPVRSPSRH PLFQVGLSYH NFTIDALELP GLRVEALDAS SSSVRFDLHV TIVDKGVDGG
PGGFDIEFGY ATDLFEEPSI RRMVDRYLRI LRSVAEDADV VVGDIDLHEP DQLAAMLEAW
EAEQLAVGPG RTLADLFDDQ ARTTPTACAL VDANSELTYG DFADRVRRLA RMLIEHGVGP
ETVVALPIRR SIDLVVAMYA VVEAGGAYLP LDPDHPRERV EYILGSADPA CILTTSRDRL
DLPGDRPTIE VDTVDLAAYS GKEIRNADRL APLRASNAAY VIYTSGSTGR PKGVVVPHEA
IVNQLVWKRK EYRLGVGDAV LLKTAATFDL SVWEFWSSLT SGAKLVVAAP DGHRDPAYLN
DLIRREHVTT LHVVPSMLDA LLDDADGELP DSLRRVLAIG EVLPVDTAER TLERSHTDLV
NLYGPTEAAV SVTAHRVTET GESSIPIGGP IPNTQVFVLD ERLHPVPPGV AGELYLAGTQ
LARGYSGRPE LTAERFVANP FGDPGTRLYR TGDLVRWRFD DDQLSGTLEY LDRADFQVKV
RGFRIELGEI ESALRALPQI RDAVVTVQHG DRIVAFVVPT GGAPDITAIR GALARTLPSY
MVPQGFVTLD ALPLNVNGKV DRKALPEAEV VTAPYRAPRT GTEATVASVY AEVLGSDDPV
GLDDDFFGIG GNSLSAVKVA ARLRDRLDAH VELPWLFLHP GVEELAARID SHSTSETDTL
GTAGLDPLLP LRSGGDGAPV FCIHPVTGLA WGFAGLVPYL GDRPVYGLQS PALGEADDLP
GDIDAWADEY VRLIRQAHPH GPYHLVGWSM GGILAHAVAV RLRRAGEQVP TLAILDAYPE
TGAARADAQP TAATAPTVAN VLGIPAEGPA AEIPLTELTA ESAQQVVQAL PAPFDSLSPE
RITRIVEGVR HSYSVLATHR PEVYDGDLTV FIAETDRPMS STEAWYPYVN GLVTTREVPV
SHWDMATRKA WAVIGPAIGR RLDERR
//
