ID V9Z2R7_9VIRU Unreviewed; 2084 AA.
AC V9Z2R7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=RNA-directed RNA polymerase L {ECO:0000256|ARBA:ARBA00018602};
DE EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
DE AltName: Full=Large structural protein {ECO:0000256|ARBA:ARBA00030285};
DE AltName: Full=Replicase {ECO:0000256|ARBA:ARBA00031012};
DE AltName: Full=Transcriptase {ECO:0000256|ARBA:ARBA00030436};
OS FTLS virus.
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Ellioviricetes; Bunyavirales; Phenuiviridae; Bandavirus;
OC Bandavirus dabieense.
OX NCBI_TaxID=1437064 {ECO:0000313|EMBL:AHE38327.1, ECO:0000313|Proteomes:UP000119572};
RN [1] {ECO:0000313|EMBL:AHE38327.1, ECO:0000313|Proteomes:UP000119572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2011YXX9 {ECO:0000313|EMBL:AHE38327.1};
RX PubMed=24633131;
RA Huang X., Du Y., Hu X., Ma H., Wang H., You A., Kang K., Chen H., Zhang L.,
RA Liu G., Xu B.;
RT "Epidemiological and etiological characteristics of Fever, thrombocytopenia
RT and leukopenia syndrome in henan province, china, 2011-2012.";
RL PLoS ONE 9:E91166-E91166(2014).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC compartment {ECO:0000256|ARBA:ARBA00004399}. Host Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004136}. Host endoplasmic reticulum-Golgi
CC intermediate compartment {ECO:0000256|ARBA:ARBA00004452}. Virion
CC {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the Bunyavirales RNA polymerase family.
CC {ECO:0000256|ARBA:ARBA00034123}.
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DR EMBL; KF711889; AHE38327.1; -; Genomic_RNA.
DR Proteomes; UP000119572; Genome.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR GO; GO:0044165; C:host cell endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR InterPro; IPR022531; L_PA-C-like.
DR InterPro; IPR029124; L_protein_N.
DR InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR InterPro; IPR007322; RNA_pol_bunyavir.
DR Pfam; PF04196; Bunya_RdRp; 1.
DR Pfam; PF12603; L_PA-C-like; 1.
DR Pfam; PF15518; L_protein_N; 1.
DR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE 3: Inferred from homology;
KW Host endoplasmic reticulum {ECO:0000256|ARBA:ARBA00023184};
KW Host Golgi apparatus {ECO:0000256|ARBA:ARBA00022812};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 969..1172
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50525"
SQ SEQUENCE 2084 AA; 235388 MW; B7848350F46ED73B CRC64;
MNLEVLCGRI NVENGLSLGE PGLYDQIYDR PGLPDLDVTV DATGVTVDIG AVPDSASQLG
SSINAGLITI QLSEAYKINH DFTFSGLSKT TDRRLSEVFP ITHDGSDGMT PDVIHTRLDG
TIVVVEFSTT RSHNIGGLEA AYRTKIEKYR DPISRRVDIM ENPRVFFGVI VVSSGGVLSN
MPLTQDEAEE LMYRFCIANE IYTKARSMDA DIELQKSEEE LEAISRALSF FSLFEPNIER
VEGTFPNSEI EMLEQFLSTP ADVDFITKTL KAKEVEAYAD LCDSHYLKPE KTIQERLEVN
RCEAIDKTQD LLAGLHARSN KQTSLNRGTV KLPPWLPKPS SESIDIKTDS GFGSLMDHGA
YGELWAKCLL DVSLGNVEGV VSDPAKELDI AISDDPDKDT PKEAKITYRR FKPALSSSAR
QEFSLQGVEG KKWKRMAANQ KKEKESHETL SPFLDVEDIG DFLTFNNLLA DSRYGDESVQ
RAVSILLEKA SAMQDTELTH ALNDSFKRNL SSNVVQWSLW VSCLAQELAS ALKQHCRAGE
FIIKKLKFWP IYVIIKPTKS SSHIFFSLGI RKADVTRRLT GRVFSETIDA GEWELTEFKS
LKTCKLTNLV NLPCTMLNSI AFWREKLGVA PWLVRKPCSE LREQVGLTFL ISLEDKSKTE
EIITLTRYTQ MEGFVSPPML PKPQKMLGKL EGPLRTKLQV YLFRKHLDCM VRIASQPFSL
ILREGRVEWG GTFHAISGRS TNLENMVNSW YIGYYKNKEE STELNALGEM YKKIVEMEED
KPSSPEFLGW GDTDSPKKHE FSRSFLRAAC SSLEREIAQR HGRQWKQNLE ERVLREIGTK
NILDLASMKA TSNFSKDWEL YSEVQTKEYH RSKLLEKMAT LIEKGVMWYI DAVGQAWKAV
LDDGCMRICL FKKNQHGGLR EIYVMDANAR LVQFGVETMA RCVCELSPHE TVANPRLKNS
IIENHGLKSA RSLGPGSINI NSSNDAKKWN QGHYTTKLAL VLCWFMPAKF HRFIWAAISM
FRKKKMMVDL RFLAHLSSKS ESRSSDPFRE AMTDAFHGNR EVSWMDKGRT YIKTETGMMQ
GILHFTSSLL HSCVQSFYKS YFVSKLKEGY MGESISGVVD VIEGSDDSAI MISIRPKSDM
DEVRSRFFVA NLLHSVKFLN PLFGIYSSEK STVNTVYCVE YNSEFHFHRH LVRPTLRWVA
ASHQISETEA LASRQEDYSN LLTQCLEGGA SFSLTYLIQC AQLLHHYMLL GLCLHPLFGT
FMGMLISDPD PALGFFLMDN PAFAGGAGFR FNLWRACKTT DLGRKYAYYF NEIQGKTKGD
EDYRALDATS GGTLSHSVMV YWGDRKKYQA LLNRMGLPED WVEQIDENPG VLYRRAANKK
ELLLKLAEKV HSPGVTSSLS KGHVVPRVVA AGVYLLSRHC FRFSSSIHGR GSTQKASLIK
LLMMSSVSAM KHGGSLNPNQ ERMLFPQAQE YDRVCTLLEE VEHLTGKFVV RERNIVRSRI
DLFQEPVDLR CKAEDLVSEV WFGLKRTKLG PRLLKEEWDK LRASFAWLST DPSETLRDGP
FLSHVQFRNF IAHVDAKSRS VRLLGAPVKK SGGVTTISQV VRMNFFPGFS LEAEKSLDNQ
ERLESISILK HVLFMVLNGP YTEEYKLEMI IEAFSTLVMP QPSEVIRKSR TMTLCLLSNY
LSSRGGSILD QIERAQSGTL GGFSKPQKTF IRPGGGVGYK GKGVWTGVME DTHVQILIDG
DGTSNWLEGI RLSSDARLYD VIESIRRLCD DLGINNRVAS AYRGHCMVRL SGFKIKPASR
TDGCPVRIME RGFRIRELQN PDEVRMRVRG DILNLSITIQ EGRVMNILSY RPRDTDISES
AAAYLWSNRD LFSFGKKEPS CSWICLKTLD NWAWSHASVL LANDRKTQGI DNRAMGNIFR
DCLEGSLRKQ GLMRSKLTEM VEKNVVPLTT QELVDILEED IDFSDVIAVE LSEGSLDIES
IFDGAPILWS AEVEEFGEGV VAVSYSSKYY HLTLMDQAAI TMCAIMGKEG CRGLLTEKRC
MAAIREQVRP FLIFLQIPED SISWVSDQFC DSRGLDEEST IMWG
//
