ID VIRB5_BRUA2 Reviewed; 238 AA.
AC Q2YJ75; Q9KIS8;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Type IV secretion system protein virB5;
DE Flags: Precursor;
GN Name=virB5; OrderedLocusNames=BAB2_0064;
OS Brucella abortus (strain 2308).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=359391;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, AND FUNCTION.
RX PubMed=10940027; DOI=10.1128/jb.182.17.4849-4855.2000;
RA Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.;
RT "A homologue of an operon required for DNA transfer in Agrobacterium is
RT required in Brucella abortus for virulence and intracellular
RT multiplication.";
RL J. Bacteriol. 182:4849-4855(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2308;
RX PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL Infect. Immun. 73:8353-8361(2005).
CC -!- FUNCTION: The virB operon is essential for intracellular survival and
CC is not involved in the invasion process. Constitutes a major
CC determinant of virulence in mice. {ECO:0000269|PubMed:10940027}.
CC -!- MISCELLANEOUS: Transcription is turned on at the beginning of the
CC stationary phase of vegetative growth.
CC -!- SIMILARITY: Belongs to the virb5 family. {ECO:0000305}.
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DR EMBL; AF226278; AAF73898.1; -; Genomic_DNA.
DR EMBL; AM040265; CAJ12230.1; -; Genomic_DNA.
DR RefSeq; WP_006077544.1; NZ_KN046823.1.
DR AlphaFoldDB; Q2YJ75; -.
DR SMR; Q2YJ75; -.
DR IntAct; Q2YJ75; 2.
DR STRING; 359391.BAB2_0064; -.
DR GeneID; 3827978; -.
DR KEGG; bmf:BAB2_0064; -.
DR PATRIC; fig|359391.11.peg.2011; -.
DR HOGENOM; CLU_096790_1_0_5; -.
DR PhylomeDB; Q2YJ75; -.
DR BioCyc; MetaCyc:BAB_RS26665-MONOMER; -.
DR PRO; PR:Q2YJ75; -.
DR Proteomes; UP000002719; Chromosome II.
DR CDD; cd14262; VirB5_like; 1.
DR Gene3D; 1.20.58.430; Type IV secretion system, VirB5-domain; 1.
DR InterPro; IPR014158; T4SS_VirB5.
DR InterPro; IPR023220; T4SS_VirB5-domain.
DR NCBIfam; TIGR02791; VirB5; 1.
DR Pfam; PF07996; T4SS; 1.
DR SUPFAM; SSF101082; Typo IV secretion system protein TraC; 1.
PE 3: Inferred from homology;
KW Reference proteome; Signal; Virulence.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..238
FT /note="Type IV secretion system protein virB5"
FT /id="PRO_0000290176"
FT REGION 219..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 238 AA; 26829 MW; E10B3F9F3E75E02E CRC64;
MKKIILSFAF ALTVTSTAHA QLPVTDAGSI AQNLANHLEQ MVKFAQQIEQ LKQQFEQQKM
QFDALTGNRG LGDILRDPTL RSYLPHNWRD LYEAVMSGGY LAAAGETANL LRKSQVYDPC
ASISDKDQRI ACEAKVVKPV QDKVMTSKAY DATDKRLQEI ESLMQEINKT GDPKAIAELQ
GRIESENAMI QNEDTRLRLY QQMAEAQDKL LDERQHELDA KDNARRGYPQ PKALEAAY
//
