ID VPB42_MYCTU Reviewed; 89 AA.
AC P9WJ19; L0TC64; O33302; Q7D6M7;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 08-NOV-2023, entry version 34.
DE RecName: Full=Putative antitoxin VapB42;
GN Name=vapB42; OrderedLocusNames=Rv2760c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP POSSIBLE FUNCTION.
RC STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA Ramage H.R., Connolly L.E., Cox J.S.;
RT "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT antitoxin systems: implications for pathogenesis, stress responses, and
RT evolution.";
RL PLoS Genet. 5:E1000767-E1000767(2009).
CC -!- FUNCTION: Possibly the antitoxin component of a type II toxin-antitoxin
CC (TA) system. Its cognate toxin is VapC42.
CC {ECO:0000305|PubMed:20011113}.
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DR EMBL; AL123456; CCP45559.1; -; Genomic_DNA.
DR PIR; G70880; G70880.
DR RefSeq; NP_217276.1; NC_000962.3.
DR RefSeq; WP_003414066.1; NZ_NVQJ01000020.1.
DR AlphaFoldDB; P9WJ19; -.
DR SMR; P9WJ19; -.
DR STRING; 83332.Rv2760c; -.
DR PaxDb; 83332-Rv2760c; -.
DR DNASU; 887705; -.
DR GeneID; 45426747; -.
DR GeneID; 887705; -.
DR KEGG; mtu:Rv2760c; -.
DR TubercuList; Rv2760c; -.
DR eggNOG; COG4423; Bacteria.
DR InParanoid; P9WJ19; -.
DR OrthoDB; 560250at2; -.
DR Proteomes; UP000001584; Chromosome.
DR InterPro; IPR011660; VapB-like.
DR Pfam; PF07704; PSK_trans_fac; 1.
PE 4: Predicted;
KW Reference proteome; Toxin-antitoxin system.
FT CHAIN 1..89
FT /note="Putative antitoxin VapB42"
FT /id="PRO_0000408083"
SQ SEQUENCE 89 AA; 10115 MW; 12D6B49C987CB8C2 CRC64;
MSLNIKSQRT VALVRELAAR TGTNQTAAVE DAVARRLSEL DREDRARAEA RRAAAEQTLR
DLDKLLSDDD KRLIRRHEVD LYDDSGLPR
//
