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Database: UniProt
Entry: VPH1_NEUCR
LinkDB: VPH1_NEUCR
Original site: VPH1_NEUCR 
ID   VPH1_NEUCR              Reviewed;         856 AA.
AC   Q01290; Q7RV48;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   07-JUN-2017, entry version 134.
DE   RecName: Full=V-type proton ATPase subunit a;
DE            Short=V-ATPase a subunit;
DE   AltName: Full=Vacuolar ATPase 98 kDa subunit;
DE   AltName: Full=Vacuolar proton pump a subunit;
DE   AltName: Full=Vacuolar proton translocating ATPase subunit a;
GN   Name=vph-1; Synonyms=vph1; ORFNames=B8J24.100, NCU03463;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM
OS   1257 / FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
OC   Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RA   Bowman E.J.;
RL   Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V.,
RA   Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J.,
RA   Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the
RT   Neurospora genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA   Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA   Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
RA   Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA   Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA   Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA   Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA   Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA   Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Subunit of the integral membrane V0 complex of vacuolar
CC       ATPase essential for assembly and catalytic activity. V-ATPase is
CC       responsible for acidifying a variety of intracellular compartments
CC       in eukaryotic cells (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme composed of a
CC       peripheral catalytic V1 complex attached to an integral membrane
CC       V0 proton pore complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000305}.
DR   EMBL; U36396; AAA93078.1; -; Genomic_DNA.
DR   EMBL; AL669990; CAD21112.1; -; Genomic_DNA.
DR   EMBL; CM002237; EAA26818.1; -; Genomic_DNA.
DR   RefSeq; XP_956054.1; XM_950961.2.
DR   PRIDE; Q01290; -.
DR   EnsemblFungi; EAA26818; EAA26818; NCU03463.
DR   GeneID; 3872192; -.
DR   KEGG; ncr:NCU03463; -.
DR   EuPathDB; FungiDB:NCU03463; -.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; Q01290; -.
DR   KO; K02154; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrogen ion transport; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW   Vacuole.
FT   CHAIN         1    856       V-type proton ATPase subunit a.
FT                                /FTId=PRO_0000119222.
FT   TOPO_DOM      1    409       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    410    428       Helical. {ECO:0000255}.
FT   TOPO_DOM    429    430       Vacuolar. {ECO:0000255}.
FT   TRANSMEM    431    447       Helical. {ECO:0000255}.
FT   TOPO_DOM    448    460       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    461    490       Helical. {ECO:0000255}.
FT   TOPO_DOM    491    544       Vacuolar. {ECO:0000255}.
FT   TRANSMEM    545    564       Helical. {ECO:0000255}.
FT   TOPO_DOM    565    582       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    583    603       Helical. {ECO:0000255}.
FT   TOPO_DOM    604    648       Vacuolar. {ECO:0000255}.
FT   TRANSMEM    649    668       Helical. {ECO:0000255}.
FT   TOPO_DOM    669    738       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    739    763       Helical. {ECO:0000255}.
FT   TOPO_DOM    764    784       Vacuolar. {ECO:0000255}.
FT   TRANSMEM    785    823       Helical. {ECO:0000255}.
FT   TOPO_DOM    824    856       Cytoplasmic. {ECO:0000255}.
SQ   SEQUENCE   856 AA;  97992 MW;  F75E3737A7DA3DE8 CRC64;
     MAPKQDTPFR SADMSMVQLY ISNEIGREVC NALGELGLVH FRDLNSELSA FQRAFTQDIR
     RLDNVERQLR YFHSQMEKAG IPLRKFDPDV DILTPPTTTE IDELAERAQT LEQRVSSLNE
     SYETLKKREV ELTEWRWVLR EAGGFFDRAH GNVEEIRAST DNDDAPLLQD VEQHNTAADV
     ERSFSGMNIG FVAGVIGRDR VDAFERILWR TLRGNLYMNQ AEIPEPLIDP TINEPVLKNV
     FVIFAHGKEI LAKIRRISES MGAEVYNVDE HSDLRRDQVH EVNARLEDVQ NVLRNTQQTL
     EAELAQISQS LSAWMITISK EKAVYNTLNL FSYDRARRTL IAEGWCPTND LPLIRSTLQD
     VNNRAGLSVP SIINEIRTNK TPPTYLKTNK FTEAFQTIVN AYGTATYQEV NPAIPVIVTF
     PFLFAVMFGD FGHALIMLCA ALAMIYWEKP LKKVTFELFA MVFYGRYIVL VMAVFSVYTG
     LIYNDVFSKS MTLFDSQWKW VVPENFKEGM TVKAVLREPN GYRYPFGLDW RWHGTENELL
     FINSYKMKMA IILGWAHMTY SLCFSYINAR HFKRPIDIWG NFVPGMIFFQ SIFGYLVLCI
     IYKWSVDWFG TGRQPPGLLN MLIYMFLQPG TLDGGVELYP GQATVQVILL LLAVIQVPIL
     LFLKPFYLRW ENNRARAKGY RGIGERSRVS ALDEDDEEDP SNGDDYEGAA MLTHDEHGDG
     EHEEFEFGEV MIHQVIHTIE FCLNSVSHTA SYLRLWALSL AHQQLSAVLW SMTMAKALES
     KGLGGAIFLV VAFAMFFVLS VIILIIMEGV SAMLHSLRLA WVESFSKFAE FGGWPFTPFS
     FKQQLEESEE LKEYIG
//
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