ID W0AG30_9SPHN Unreviewed; 401 AA.
AC W0AG30;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:AHE55243.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:AHE55243.1};
GN ORFNames=NX02_17845 {ECO:0000313|EMBL:AHE55243.1};
OS Sphingomonas sanxanigenens DSM 19645 = NX02.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1123269 {ECO:0000313|EMBL:AHE55243.1, ECO:0000313|Proteomes:UP000018851};
RN [1] {ECO:0000313|EMBL:AHE55243.1, ECO:0000313|Proteomes:UP000018851}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NX02 {ECO:0000313|EMBL:AHE55243.1,
RC ECO:0000313|Proteomes:UP000018851};
RA Ma T., Huang H., Wu M., Li X., Li G.;
RT "Completed genome of Sphingomonas sanxanigenens NX02.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; CP006644; AHE55243.1; -; Genomic_DNA.
DR RefSeq; WP_025293428.1; NZ_CP006644.1.
DR AlphaFoldDB; W0AG30; -.
DR STRING; 1123269.NX02_17845; -.
DR KEGG; ssan:NX02_17845; -.
DR PATRIC; fig|1123269.5.peg.3494; -.
DR eggNOG; COG0183; Bacteria.
DR HOGENOM; CLU_031026_1_1_5; -.
DR OrthoDB; 7181944at2; -.
DR Proteomes; UP000018851; Chromosome.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF22; ACETYL-COA ACETYLTRANSFERASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:AHE55243.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018851};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:AHE55243.1}.
FT DOMAIN 6..270
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 280..399
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 91
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 357
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 387
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 401 AA; 42065 MW; 0D8C466E9A478838 CRC64;
MTREAAIVST ARTPIGRAGR GAFNNTEPTV LAGHVMHAAI ERAGIDPERI DDVFWGAGNQ
YGQQFYNIGR MASFAAGLPQ SVAGFSVDRK CGSGLTTVAL AARSIICGDI DVALAGGGES
VTYTSLPGMV TPDWRSQAVI AQEPDAYMAM IETAEIVAER YGISREVQDR FAVESQHRAA
AATAAGRYAD EIVPLTAEKI LRAKDGSETG RETVTLAADE GIRADTSYEG LASLKPVWKG
GKTVAEGRFV TAGNASQLSD GASAQVVMDR ATAEAEGREV LGLFRGFQVA GCGPEEMGIG
PVLAVPKLLA RAGLKVEDVG LWEINEAFAS QVVYCRDKLG IDPDRFNVDG GAIAIGHPFG
MTGSRLVGHA LIEGRRRGVR YVVVSMCVAG GIGAAGLFEI V
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