ID   W0AHW5_9SPHN            Unreviewed;       360 AA.
AC   W0AHW5;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0000259|SMART:SM00829};
GN   ORFNames=NX02_17855 {ECO:0000313|EMBL:AHE55245.1};
OS   Sphingomonas sanxanigenens DSM 19645 = NX02.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=1123269 {ECO:0000313|EMBL:AHE55245.1, ECO:0000313|Proteomes:UP000018851};
RN   [1] {ECO:0000313|EMBL:AHE55245.1, ECO:0000313|Proteomes:UP000018851}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NX02 {ECO:0000313|EMBL:AHE55245.1,
RC   ECO:0000313|Proteomes:UP000018851};
RA   Ma T., Huang H., Wu M., Li X., Li G.;
RT   "Completed genome of Sphingomonas sanxanigenens NX02.";
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; CP006644; AHE55245.1; -; Genomic_DNA.
DR   RefSeq; WP_025293430.1; NZ_CP006644.1.
DR   AlphaFoldDB; W0AHW5; -.
DR   STRING; 1123269.NX02_17855; -.
DR   KEGG; ssan:NX02_17855; -.
DR   PATRIC; fig|1123269.5.peg.3496; -.
DR   eggNOG; COG1062; Bacteria.
DR   HOGENOM; CLU_026673_14_1_5; -.
DR   OrthoDB; 9770544at2; -.
DR   Proteomes; UP000018851; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08279; Zn_ADH_class_III; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR   PANTHER; PTHR43880:SF12; ALCOHOL DEHYDROGENASE CLASS-3; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018851};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          10..357
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   360 AA;  37467 MW;  A5ED73D2C15C1A23 CRC64;
     MKAAVLRQVG APLVIEDVAI ADPAPHEVRI RTVATGVCHS DLHFLEGSYP TALPTILGHE
     SAGVVEAVGS EVRTVKVGDH VVTCLSAFCG HCEHCVTGHL SRCHAPDVQR GAEDPPRLGT
     GDMPMAQFLN LSGFAETMLV HEHACVAIRP DMPLDRAALI GCAVLTGYGA IVHTAQVRPG
     ETVAVIGCGG VGFAAINAAA IAGAARIIAV DRVAAKEALA RTFGATDFVD ASSDDAAKQV
     VAMTRGGVHH AFEAIGLAST AELAFAMLRR GGAATVIGMI PIGQKVSIAG YQLLAEKTLR
     GSLMGSNRFP VDVPRIVDLY LAGKLKLDEL ISRRIGLGDV NEAFTEMKSG TIARSVITFA
//