ID W0ED01_9FIRM Unreviewed; 624 AA.
AC W0ED01;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Biotin carboxyl carrier protein of acetyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00017562};
GN ORFNames=DESME_10445 {ECO:0000313|EMBL:AHF07403.1};
OS Desulfitobacterium metallireducens DSM 15288.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfitobacteriaceae;
OC Desulfitobacterium.
OX NCBI_TaxID=871968 {ECO:0000313|EMBL:AHF07403.1, ECO:0000313|Proteomes:UP000010847};
RN [1] {ECO:0000313|EMBL:AHF07403.1, ECO:0000313|Proteomes:UP000010847}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15288 {ECO:0000313|Proteomes:UP000010847};
RG DOE Joint Genome Institute;
RA Smidt H., Huntemann M., Han J., Chen A., Kyrpides N., Mavromatis K.,
RA Markowitz V., Palaniappan K., Ivanova N., Schaumberg A., Pati A.,
RA Liolios K., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T.;
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
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DR EMBL; CP007032; AHF07403.1; -; Genomic_DNA.
DR RefSeq; WP_006716065.1; NZ_CP007032.1.
DR AlphaFoldDB; W0ED01; -.
DR STRING; 871968.DESME_10445; -.
DR KEGG; dmt:DESME_10445; -.
DR eggNOG; COG0511; Bacteria.
DR eggNOG; COG5016; Bacteria.
DR HOGENOM; CLU_000395_4_3_9; -.
DR OrthoDB; 9807469at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000010847; Chromosome.
DR GO; GO:0009317; C:acetyl-CoA carboxylase complex; IEA:InterPro.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro.
DR GO; GO:0004736; F:pyruvate carboxylase activity; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06850; biotinyl_domain; 1.
DR CDD; cd07937; DRE_TIM_PC_TC_5S; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR001249; AcCoA_biotinCC.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR003379; Carboxylase_cons_dom.
DR InterPro; IPR000891; PYR_CT.
DR InterPro; IPR011053; Single_hybrid_motif.
DR NCBIfam; TIGR00531; BCCP; 1.
DR PANTHER; PTHR45266; OXALOACETATE DECARBOXYLASE ALPHA CHAIN; 1.
DR PANTHER; PTHR45266:SF3; OXALOACETATE DECARBOXYLASE ALPHA CHAIN; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR Pfam; PF02436; PYC_OADA; 1.
DR PRINTS; PR01071; ACOABIOTINCC.
DR SUPFAM; SSF51569; Aldolase; 1.
DR SUPFAM; SSF89000; post-HMGL domain-like; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 4: Predicted;
KW Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Reference proteome {ECO:0000313|Proteomes:UP000010847}.
FT DOMAIN 4..264
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
FT DOMAIN 547..623
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 624 AA; 68467 MW; A84F1F0FC70BF178 CRC64;
MKKIGITDTT LRDGHQSLWA TRMRTEDMLP ILRELDDAGY HSLEVWGGAT FDVCLRFLGE
DPWERLRLIK SEVKKTPLQM LLRGQSLVGY QHYPDDVVRE FIQLSVKNGI DIIRIFDALN
DVRNMVVPIQ AAKEAGAHVQ ASVVYTISPV HTVEHYLETA RELVKLGADS ICIKDMAGLL
TPLKAYKLVK LLKDELGVMI QLHTHYIGGM GTIAYVKAAE AGVDVIDTAS VPLAFGASQP
PVETVVRALG DYNFASDINI PHLFKIANYF EGIRKARGYE RGITRISDMR VFEHQVPGGM
ISNLVSQLEE QKALNRIDEV LDEIPRVRAE LGYPPLVTPT SQIVGTQAVL NVLSGERYKL
VPGEVKAYVK GQYGKPPAEV DPLIQKKIIG DEIPLTERPA DKLLPGLEKA ENECAGLARS
REDVLSYAVF PQVAKKFFLE RQKGGSKSGV ELKPANSKED SKMNLKEIKE LIKLLGETDI
AEVNLESEGV KVSIKKGSAF STSQTVAVPT MATVTAPAPV VAPAQVAPMA QGKVEIVSAD
TSAKTNFEYI KSPMVGTFYR TPAPDAPSFV ELGQTVKLGQ AVCIIEAMKL MNEIEAEVEG
KVVEVLVENG QPVEFGQPLF AIEK
//
