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Database: UniProt
Entry: W0HVP4_9GAMM
LinkDB: W0HVP4_9GAMM
Original site: W0HVP4_9GAMM 
ID   W0HVP4_9GAMM            Unreviewed;       245 AA.
AC   W0HVP4;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   07-JUN-2017, entry version 25.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00634471};
GN   Name=hda {ECO:0000256|HAMAP-Rule:MF_01158,
GN   ECO:0000313|EMBL:AHF76275.1};
GN   ORFNames=Sant_1206 {ECO:0000313|EMBL:AHF76275.1};
OS   Sodalis praecaptivus.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Sodalis.
OX   NCBI_TaxID=1239307 {ECO:0000313|EMBL:AHF76275.1, ECO:0000313|Proteomes:UP000019028};
RN   [1] {ECO:0000313|EMBL:AHF76275.1, ECO:0000313|Proteomes:UP000019028}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HS1 {ECO:0000313|EMBL:AHF76275.1,
RC   ECO:0000313|Proteomes:UP000019028};
RX   PubMed=24407854; DOI=10.1093/gbe/evt210;
RA   Oakeson K.F., Gil R., Clayton A.L., Dunn D.M., von Niederhausern A.C.,
RA   Hamil C., Aoyagi A., Duval B., Baca A., Silva F.J., Vallier A.,
RA   Jackson D.G., Latorre A., Weiss R.B., Heddi A., Moya A., Dale C.;
RT   "Genome degeneration and adaptation in a nascent stage of symbiosis.";
RL   Genome Biol. Evol. 6:76-93(2014).
CC   -!- FUNCTION: Mediates the interaction of DNA replication inititator
CC       protein DnaA with DNA polymerase subunit beta sliding clamp
CC       (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering
CC       DnaA inactive for reinititation, a process called regulatory
CC       inhibition of DnaA or RIDA. {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms
CC       the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA,
CC       ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).
CC       {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00548763}.
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DR   EMBL; CP006569; AHF76275.1; -; Genomic_DNA.
DR   RefSeq; WP_071882003.1; NZ_CP006569.1.
DR   EnsemblBacteria; AHF76275; AHF76275; Sant_1206.
DR   KEGG; sod:Sant_1206; -.
DR   PATRIC; fig|1239307.3.peg.1292; -.
DR   KO; K10763; -.
DR   Proteomes; UP000019028; Chromosome.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-HAMAP.
DR   GO; GO:0032297; P:negative regulation of DNA-dependent DNA replication initiation; IEA:InterPro.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000019028};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634466};
KW   DNA replication inhibitor {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634468};
KW   Initiation factor {ECO:0000313|EMBL:AHF76275.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:AHF76275.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019028}.
FT   DOMAIN       28    224       Bac_DnaA. {ECO:0000259|Pfam:PF00308}.
SQ   SEQUENCE   245 AA;  27715 MW;  7DF319E814AB0276 CRC64;
     MAKIFARTQE VHLNTPAQLS LPLYLPDDET FASFYPGENG ALLAALQEML SREHGSYLYF
     WSRKGGGRSH LLHAACAALS ARTQAVGYVP LDKRTWFVPE VLEGMEQLAL VTIDNIECIV
     GDPPWEMAIF NLYNRIQETG RTRLIISGNC PPRQLNLSLP DLASRLDWGQ IYRLQPLSDE
     EKGAALQLRA KLRGFELPED VSRFLLKRLE RDMRTLSATL DQLDHASIRA QRKLTIPFVK
     AILNL
//
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