ID W0NZP0_BUCMP Unreviewed; 804 AA.
AC W0NZP0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 13-SEP-2023, entry version 48.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=muts {ECO:0000313|EMBL:AHG59966.1};
GN Synonyms=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=BUMPUSDA_CDS00170 {ECO:0000313|EMBL:AHG59966.1};
OS Buchnera aphidicola str. USDA (Myzus persicae).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Buchnera.
OX NCBI_TaxID=1009856 {ECO:0000313|EMBL:AHG59966.1, ECO:0000313|Proteomes:UP000019087};
RN [1] {ECO:0000313|EMBL:AHG59966.1, ECO:0000313|Proteomes:UP000019087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=str. USDA (Myzus persicae) {ECO:0000313|Proteomes:UP000019087};
RX PubMed=24365332; DOI=10.1186/1471-2164-14-917;
RA Jiang Z., Jones D.H., Khuri S., Tsinoremas N.F., Wyss T., Jander G.,
RA Wilson A.C.;
RT "Comparative analysis of genome sequences from four strains of the Buchnera
RT aphidicola Mp endosymbion of the green peach aphid, Myzus persicae.";
RL BMC Genomics 14:917-917(2013).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP002697; AHG59966.1; -; Genomic_DNA.
DR AlphaFoldDB; W0NZP0; -.
DR KEGG; bapu:BUMPUSDA_CDS00170; -.
DR PATRIC; fig|1009856.3.peg.419; -.
DR HOGENOM; CLU_002472_4_0_6; -.
DR Proteomes; UP000019087; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 632..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 693..709
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 619..626
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 804 AA; 92732 MW; 05AD6A5918393053 CRC64;
MIKKINIDTQ LNNHTPMIKQ YLSLKLQYPD MLLFYQMGDF YELFYDDAER ISKLLKITLT
KKGYSNNNII PMAGIPCHTA EYYLSKLVKL GESIAVCDQI KENPLKKNKL ITRKVVRVIT
PGTITDEAFL EENEDNFIAS IWKENNQFGY AVLDISLGFF GVSKHFSITS ILAEIERTNP
KEILYPENFS DFFLIENRKC TRQRLLSEFD LTNSYNLLNL QFKTHTLKGF GIEKDDFIIR
PAGCLLQYVK LMHMTILPHI RNIKNNYIEE NISMNVNTRK SLEITRNIFG ETKNTLSSIL
NKTVTSMGSR MLNRWLHSPL KNFKIVKNRH ESVKILKLFY KELQPILRQI NDLERIYSRL
ALRTASPHDF IRMRSTLKIL PKLHVILKKI KFKHIKNIRL SIGSFDEILI LLNKSISINA
SKSIRDGGVI ASNYNVQLDD LRNIKINSID YIKNFEYQEK RKLMIESFKI RFNHIIGYYI
QVNKRHAHLI PEHYTRIQTL KNTERYSVSF LKQHEEKVSN SVIQSLLLEK KLYEEIFDII
EPFLEQLKDS ASALSELDVL SNLSERAVSL NYVCPIMTKK YGISLLDSRH PVVEYFLKTP
FINNSVVLSK KQRMLIITGP NMGGKSTYMR QIALIVIMAW VGSFVPAKFA LIGIIDKIFT
RIGAGDDLSN GCSTFMMEMT EISNILNNAT SHSLVLIDEL GRGTSMNEGL SLAWSCSQYL
IDKIKSMTLL STHFFELTKL ELKNNSVKNF HFTAVESHLH IAFLYKIKPG ISRKSYGISV
ASLSGLPDIV IQHAKEKLID LENI
//
