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Database: UniProt
Entry: W0U604_9FIRM
LinkDB: W0U604_9FIRM
Original site: W0U604_9FIRM 
ID   W0U604_9FIRM            Unreviewed;       497 AA.
AC   W0U604;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=non-specific protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011903};
DE            EC=2.7.10.2 {ECO:0000256|ARBA:ARBA00011903};
GN   Name=epsB {ECO:0000313|EMBL:CCO04979.1};
GN   ORFNames=RBI_I01267 {ECO:0000313|EMBL:CCO04979.1};
OS   Ruminococcus bicirculans (ex Wegman et al. 2014).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Ruminococcus.
OX   NCBI_TaxID=1160721 {ECO:0000313|EMBL:CCO04979.1, ECO:0000313|Proteomes:UP000027600};
RN   [1] {ECO:0000313|EMBL:CCO04979.1, ECO:0000313|Proteomes:UP000027600}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=80/3 {ECO:0000313|EMBL:CCO04979.1};
RX   PubMed=23919528; DOI=10.1111/1462-2920.12217;
RA   Wegmann U., Louis P., Goesmann A., Henrissat B., Duncan S.H., Flint H.J.;
RT   "Complete genome of a new Firmicutes species belonging to the dominant
RT   human colonic microbiota ('Ruminococcus bicirculans') reveals two
RT   chromosomes and a selective capacity to utilize plant glucans.";
RL   Environ. Microbiol. 16:2879-2890(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001149};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CpsD/CapB family.
CC       {ECO:0000256|ARBA:ARBA00007316}.
CC   -!- SIMILARITY: Belongs to the etk/wzc family.
CC       {ECO:0000256|ARBA:ARBA00008883}.
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DR   EMBL; HF545616; CCO04979.1; -; Genomic_DNA.
DR   RefSeq; WP_051706559.1; NZ_HF545616.1.
DR   AlphaFoldDB; W0U604; -.
DR   STRING; 1160721.RBI_I01267; -.
DR   GeneID; 41519312; -.
DR   KEGG; rus:RBI_I01267; -.
DR   eggNOG; COG0489; Bacteria.
DR   eggNOG; COG3944; Bacteria.
DR   HOGENOM; CLU_009912_4_2_9; -.
DR   OrthoDB; 9794577at2; -.
DR   Proteomes; UP000027600; Chromosome I.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05387; BY-kinase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR025669; AAA_dom.
DR   InterPro; IPR003856; LPS_length_determ_N_term.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005702; Wzc-like_C.
DR   NCBIfam; TIGR01007; eps_fam; 1.
DR   PANTHER; PTHR32309:SF30; EXOPOLYSACCHARIDE POLYMERIZATION PROTEIN-RELATED; 1.
DR   PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR   Pfam; PF13614; AAA_31; 1.
DR   Pfam; PF02706; Wzz; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CCO04979.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CCO04979.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT   TRANSMEM        18..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        196..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          7..99
FT                   /note="Polysaccharide chain length determinant N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02706"
FT   DOMAIN          294..423
FT                   /note="AAA"
FT                   /evidence="ECO:0000259|Pfam:PF13614"
SQ   SEQUENCE   497 AA;  54888 MW;  5A4517513A612721 CRC64;
     MKKNYTIKDL LVLLLGKVWY IVAASIVCAI LALFVSKFVM SKQYQSHVSM YVKSADNQST
     GQDKTNVDLQ DINASKSLVQ TYIVILTDDP VMNEVSDKLL EMYTPEQLAP YFTVTSGRVS
     NDDLRNAYSM IAVNQTEVLQ ITATTTNAKL SSDLCNIMAD VAPSFLIRVI GAGSVEKIGD
     AEVYNTPVSP NTTKNVALGF VGGLMVAVLV ILVIDFFDNT VKNSDELGDI YQKPIVGEIM
     NIGGKTSKKD EGSSADRKKQ LLFNNKDIPF NIVENYKTMR TNLMFTLSTT RNKIVVVSSP
     NPSEGKSVTV ANLAASMAET ENKVLLIDAD MRRPVQHRNF KLKNNVGLST ILSGESTFDK
     CVHETKNGNF AVLTSGVLPP NPSELLASEK MRELLEYVQH KYDYVIVDGT PLLPVTDVMS
     LADEVAGVLL VARYGRTTYQ EIEESMKKLE IGDCNLLGFV LNDISAKNGS HYGYKYSYKY
     KYDYSYKYGG KDASAES
//
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