ID W0U604_9FIRM Unreviewed; 497 AA.
AC W0U604;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=non-specific protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011903};
DE EC=2.7.10.2 {ECO:0000256|ARBA:ARBA00011903};
GN Name=epsB {ECO:0000313|EMBL:CCO04979.1};
GN ORFNames=RBI_I01267 {ECO:0000313|EMBL:CCO04979.1};
OS Ruminococcus bicirculans (ex Wegman et al. 2014).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=1160721 {ECO:0000313|EMBL:CCO04979.1, ECO:0000313|Proteomes:UP000027600};
RN [1] {ECO:0000313|EMBL:CCO04979.1, ECO:0000313|Proteomes:UP000027600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=80/3 {ECO:0000313|EMBL:CCO04979.1};
RX PubMed=23919528; DOI=10.1111/1462-2920.12217;
RA Wegmann U., Louis P., Goesmann A., Henrissat B., Duncan S.H., Flint H.J.;
RT "Complete genome of a new Firmicutes species belonging to the dominant
RT human colonic microbiota ('Ruminococcus bicirculans') reveals two
RT chromosomes and a selective capacity to utilize plant glucans.";
RL Environ. Microbiol. 16:2879-2890(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001149};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CpsD/CapB family.
CC {ECO:0000256|ARBA:ARBA00007316}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; HF545616; CCO04979.1; -; Genomic_DNA.
DR RefSeq; WP_051706559.1; NZ_HF545616.1.
DR AlphaFoldDB; W0U604; -.
DR STRING; 1160721.RBI_I01267; -.
DR GeneID; 41519312; -.
DR KEGG; rus:RBI_I01267; -.
DR eggNOG; COG0489; Bacteria.
DR eggNOG; COG3944; Bacteria.
DR HOGENOM; CLU_009912_4_2_9; -.
DR OrthoDB; 9794577at2; -.
DR Proteomes; UP000027600; Chromosome I.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309:SF30; EXOPOLYSACCHARIDE POLYMERIZATION PROTEIN-RELATED; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CCO04979.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CCO04979.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 18..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..99
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 294..423
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 497 AA; 54888 MW; 5A4517513A612721 CRC64;
MKKNYTIKDL LVLLLGKVWY IVAASIVCAI LALFVSKFVM SKQYQSHVSM YVKSADNQST
GQDKTNVDLQ DINASKSLVQ TYIVILTDDP VMNEVSDKLL EMYTPEQLAP YFTVTSGRVS
NDDLRNAYSM IAVNQTEVLQ ITATTTNAKL SSDLCNIMAD VAPSFLIRVI GAGSVEKIGD
AEVYNTPVSP NTTKNVALGF VGGLMVAVLV ILVIDFFDNT VKNSDELGDI YQKPIVGEIM
NIGGKTSKKD EGSSADRKKQ LLFNNKDIPF NIVENYKTMR TNLMFTLSTT RNKIVVVSSP
NPSEGKSVTV ANLAASMAET ENKVLLIDAD MRRPVQHRNF KLKNNVGLST ILSGESTFDK
CVHETKNGNF AVLTSGVLPP NPSELLASEK MRELLEYVQH KYDYVIVDGT PLLPVTDVMS
LADEVAGVLL VARYGRTTYQ EIEESMKKLE IGDCNLLGFV LNDISAKNGS HYGYKYSYKY
KYDYSYKYGG KDASAES
//