ID W0V4Y4_9BURK Unreviewed; 605 AA.
AC W0V4Y4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Type 3 secretion system secretin {ECO:0000256|HAMAP-Rule:MF_02219};
DE Short=T3SS secretin {ECO:0000256|HAMAP-Rule:MF_02219};
DE Flags: Precursor;
GN Name=sctC {ECO:0000256|HAMAP-Rule:MF_02219};
GN ORFNames=GJA_1694 {ECO:0000313|EMBL:CDG82332.1};
OS Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Janthinobacterium.
OX NCBI_TaxID=1349767 {ECO:0000313|EMBL:CDG82332.1, ECO:0000313|Proteomes:UP000027604};
RN [1] {ECO:0000313|EMBL:CDG82332.1, ECO:0000313|Proteomes:UP000027604}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 102515 / DSM 9628 {ECO:0000313|Proteomes:UP000027604};
RX PubMed=25883287; DOI=10.1128/genomeA.00277-15;
RA Graupner K., Lackner G., Hertweck C.;
RT "Genome Sequence of Mushroom Soft-Rot Pathogen Janthinobacterium
RT agaricidamnosum.";
RL Genome Announc. 3:e00277-e00277(2015).
CC -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC called injectisome, which is used to inject bacterial effector proteins
CC into eukaryotic host cells. Forms a ring-shaped multimeric structure
CC with an apparent central pore in the outer membrane.
CC {ECO:0000256|HAMAP-Rule:MF_02219}.
CC -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC approximately 20 different proteins, including cytoplasmic components,
CC a base, an export apparatus and a needle. This subunit is part of the
CC base, which anchors the injectisome in the bacterial cell envelope.
CC Forms a stable homooligomeric complex. {ECO:0000256|HAMAP-
CC Rule:MF_02219}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000256|HAMAP-
CC Rule:MF_02219, ECO:0000256|RuleBase:RU004004}.
CC -!- SIMILARITY: Belongs to the bacterial secretin family. T3SS SctC
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_02219}.
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DR EMBL; HG322949; CDG82332.1; -; Genomic_DNA.
DR RefSeq; WP_051780437.1; NZ_HG322949.1.
DR AlphaFoldDB; W0V4Y4; -.
DR STRING; 1349767.GJA_1694; -.
DR KEGG; jag:GJA_1694; -.
DR PATRIC; fig|1349767.4.peg.3371; -.
DR eggNOG; COG1450; Bacteria.
DR HOGENOM; CLU_022474_1_0_4; -.
DR Proteomes; UP000027604; Chromosome I.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030257; C:type III protein secretion system complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.120; -; 2.
DR Gene3D; 3.55.50.30; -; 1.
DR HAMAP; MF_02219; Type_III_secretin; 1.
DR InterPro; IPR005644; NolW-like.
DR InterPro; IPR038591; NolW-like_sf.
DR InterPro; IPR004846; T2SS/T3SS_dom.
DR InterPro; IPR003522; T3SS_OM_pore_YscC.
DR NCBIfam; TIGR02516; type_III_yscC; 1.
DR PANTHER; PTHR30332; PROBABLE GENERAL SECRETION PATHWAY PROTEIN D; 1.
DR PANTHER; PTHR30332:SF5; SPI-1 TYPE 3 SECRETION SYSTEM SECRETIN; 1.
DR Pfam; PF00263; Secretin; 1.
DR Pfam; PF03958; Secretin_N; 1.
DR PRINTS; PR01337; TYPE3OMGPROT.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|HAMAP-Rule:MF_02219};
KW Membrane {ECO:0000256|HAMAP-Rule:MF_02219};
KW Protein transport {ECO:0000256|HAMAP-Rule:MF_02219};
KW Reference proteome {ECO:0000313|Proteomes:UP000027604};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|HAMAP-Rule:MF_02219};
KW Translocation {ECO:0000256|HAMAP-Rule:MF_02219};
KW Transport {ECO:0000256|HAMAP-Rule:MF_02219, ECO:0000256|RuleBase:RU004004}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02219"
FT CHAIN 32..605
FT /note="Type 3 secretion system secretin"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02219"
FT /id="PRO_5026398433"
FT DOMAIN 189..310
FT /note="NolW-like"
FT /evidence="ECO:0000259|Pfam:PF03958"
FT DOMAIN 376..532
FT /note="Type II/III secretion system secretin-like"
FT /evidence="ECO:0000259|Pfam:PF00263"
FT REGION 245..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 64991 MW; 4364A6F8277A0327 CRC64;
MNHSHFSSWR RALLLAASLA VPLMTALPAA ASTPANWKDT AYSVDANGMG LEKVLAEFAT
AYGVRVESSL TEASRVKGRI KADSGSDFLD RLGATQHFRW FVYNATLYIV PDGDYTTARL
NIGEAAVPDA KPALVGLGLF DSRFGWGELP EDGAVIVSGP RPYVELARKL LTPTAKEKGV
APQDKQIMVF RLKYANATDR TIDRRGQKET IPGLKTILSG MINNDTQART EAPAERVAKS
PYQKLGMLPA ENPDPGLAPA AQPRNKGGEQ KQRIRIDADP TLNALIVYDL PEKRDMYRAL
LDELDVEPRQ IEIEALIIDI DRDKLAELGV EWSVTSGNTT TTVNGTGANS NGTDTPLPGS
TLLINNLGRF YARLHALEGS GEAHVLAKPT IMTLDNVPAV LDLSQTAYVP LVGERVADLA
NISVGTLLRV VPRLVHDGSA QRVHLEVDVE DGSLGDSSNN ANTKVTRSNI STQAIINLQQ
TLMIGGYHAE KLNRQNQKVP LLGDLPLIGG MFRSSSDSQS SRERLFLITP RLTGDGIAAT
PQSSVQVQAN TLLAAAAAQV PAGLAPALAA PGAIAAKPPR ARCKGRRSVG NAQLNSYLDM
VRSNR
//
