ID W0V5R8_9BURK Unreviewed; 317 AA.
AC W0V5R8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein {ECO:0000313|EMBL:CDG83231.1};
GN ORFNames=GJA_2600 {ECO:0000313|EMBL:CDG83231.1};
OS Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Janthinobacterium.
OX NCBI_TaxID=1349767 {ECO:0000313|EMBL:CDG83231.1, ECO:0000313|Proteomes:UP000027604};
RN [1] {ECO:0000313|EMBL:CDG83231.1, ECO:0000313|Proteomes:UP000027604}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 102515 / DSM 9628 {ECO:0000313|Proteomes:UP000027604};
RX PubMed=25883287; DOI=10.1128/genomeA.00277-15;
RA Graupner K., Lackner G., Hertweck C.;
RT "Genome Sequence of Mushroom Soft-Rot Pathogen Janthinobacterium
RT agaricidamnosum.";
RL Genome Announc. 3:e00277-e00277(2015).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; HG322949; CDG83231.1; -; Genomic_DNA.
DR RefSeq; WP_038492526.1; NZ_HG322949.1.
DR AlphaFoldDB; W0V5R8; -.
DR STRING; 1349767.GJA_2600; -.
DR KEGG; jag:GJA_2600; -.
DR PATRIC; fig|1349767.4.peg.4330; -.
DR eggNOG; COG1052; Bacteria.
DR HOGENOM; CLU_019796_1_2_4; -.
DR OrthoDB; 9805416at2; -.
DR Proteomes; UP000027604; Chromosome I.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12156; HPPR; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000027604}.
FT DOMAIN 15..315
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 111..284
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 317 AA; 32973 MW; 1E1C5B56A40DDF4D CRC64;
MKPEILVVAA SPSSSVMAQL EQQFHCHHLW QVAAGGRDAF IRQVGAGVRG VVTTGALGLN
ARDIGLLPAL EIIAINGIGI DGVALDVTRA RGIAVTTTPD VLTDDVADLA LTLLLSAARR
LPALDQYVRD GSWERRASLA PASSLRGKQA GIFGFGRIGQ AIARRLTAFG LELAYYQPRP
IAGAEVPRAA SLLELAQRSD YLVVCAPGGT DTRHAINAGV LAALGPKGTL VNIARGSLVD
EDALIAALQT GALGAAGLDV FADEPRVPAA LRALPNVVLT PHVGSLTEET RHAMGQLVVD
NLTAHFAGRP LLTPVKS
//
