ID W1DHQ3_KLEPN Unreviewed; 275 AA.
AC W1DHQ3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000313|EMBL:CDL08277.1};
DE EC=2.3.1.12 {ECO:0000313|EMBL:CDL08277.1};
OS Klebsiella pneumoniae IS43.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1432552 {ECO:0000313|EMBL:CDL08277.1, ECO:0000313|Proteomes:UP000019183};
RN [1] {ECO:0000313|EMBL:CDL08277.1, ECO:0000313|Proteomes:UP000019183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IS43 {ECO:0000313|EMBL:CDL08277.1,
RC ECO:0000313|Proteomes:UP000019183};
RA Barisic I., Mitteregger D., Hirschl A.M., Noehammer C., Wiesinger-Mayr H.;
RT "Antibiotic resistance diversity of beta-lactamase producers in the General
RT Hospital Vienna.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDL08277.1}.
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DR EMBL; CBWK010000177; CDL08277.1; -; Genomic_DNA.
DR AlphaFoldDB; W1DHQ3; -.
DR eggNOG; COG0508; Bacteria.
DR Proteomes; UP000019183; Unassembled WGS sequence.
DR GO; GO:0045254; C:pyruvate dehydrogenase complex; IEA:InterPro.
DR GO; GO:0004742; F:dihydrolipoyllysine-residue acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IEA:InterPro.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR045257; E2/Pdx1.
DR PANTHER; PTHR23151; DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED; 1.
DR PANTHER; PTHR23151:SF90; DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:CDL08277.1};
KW Pyruvate {ECO:0000313|EMBL:CDL08277.1};
KW Transferase {ECO:0000313|EMBL:CDL08277.1}.
FT DOMAIN 41..267
FT /note="2-oxoacid dehydrogenase acyltransferase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00198"
SQ SEQUENCE 275 AA; 29768 MW; C5F08C6D42783492 CRC64;
MHDCRSSGSR GRVSRDDVLA AALLLDEHPQ TSPVQESAPA PFESIPMSGM RRAIASRLQT
SKQQSPHFRL SVDLDLERLL ALRQDINREV PGVKISVNDL LVKACALALV AVPDVNIQFD
EAAQSIRRFT DADISVAVAL PAGLITPIVR SANRKSISDI SNEIHSLVTR AKAGTLKPEE
FQGGTFSLSN LGMLGVRQFD AIINPPQSAI LAIGAGEVRA VVRDGQIVAR QQMTVSLSCD
HRVIDGAAGA AFLRELKRLI ETPTLMFIQE TSYAR
//
