ID W1DIC8_KLEPN Unreviewed; 273 AA.
AC W1DIC8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=HTH-type transcriptional regulator HdfR {ECO:0000256|HAMAP-Rule:MF_01233};
DE AltName: Full=H-NS-dependent flhDC regulator {ECO:0000256|HAMAP-Rule:MF_01233};
GN Name=hdfR {ECO:0000256|HAMAP-Rule:MF_01233};
OS Klebsiella pneumoniae IS43.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1432552 {ECO:0000313|EMBL:CDL08497.1, ECO:0000313|Proteomes:UP000019183};
RN [1] {ECO:0000313|EMBL:CDL08497.1, ECO:0000313|Proteomes:UP000019183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IS43 {ECO:0000313|EMBL:CDL08497.1,
RC ECO:0000313|Proteomes:UP000019183};
RA Barisic I., Mitteregger D., Hirschl A.M., Noehammer C., Wiesinger-Mayr H.;
RT "Antibiotic resistance diversity of beta-lactamase producers in the General
RT Hospital Vienna.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negatively regulates the transcription of the flagellar
CC master operon flhDC by binding to the upstream region of the operon.
CC {ECO:0000256|HAMAP-Rule:MF_01233}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000256|ARBA:ARBA00009437, ECO:0000256|HAMAP-Rule:MF_01233}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDL08497.1}.
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DR EMBL; CBWK010000210; CDL08497.1; -; Genomic_DNA.
DR AlphaFoldDB; W1DIC8; -.
DR eggNOG; COG0583; Bacteria.
DR Proteomes; UP000019183; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01233; HTH_type_HdfR; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR020890; Tscrpt_reg_HTH_HdfR.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30579:SF8; HTH-TYPE TRANSCRIPTIONAL REGULATOR HDFR; 1.
DR PANTHER; PTHR30579; TRANSCRIPTIONAL REGULATOR; 1.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01233};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_01233};
KW Transcription {ECO:0000256|HAMAP-Rule:MF_01233};
KW Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01233}.
FT DOMAIN 1..58
FT /note="HTH lysR-type"
FT /evidence="ECO:0000259|PROSITE:PS50931"
FT DNA_BIND 18..37
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01233"
SQ SEQUENCE 273 AA; 31303 MW; 06D1EBB6E313B314 CRC64;
MDTELLKTFL EVSRTRHFGR AAEALYLTQS AVSFRIRQLE NQLGVNLFTR HRNNIRLTTA
GEKLLPYAET LMNTWQAARK EVAHSSRHNE FSIGASASLW ECMLNSWLDT LYSAPYNLQF
EARIAQRQSL VKQLHERQLD LLITTESPKM DELSSQLLGN FTLALYCASP AKNRNELNYL
RLEWGPDFQQ NEVGLIGSDD VPLLTTSSAE LIYQQLSRLN GCCWLPARWA KEKHGLHTVM
DSATLSRPLY AIWLQNSDKQ AQIHEILKNP ILE
//
