ID   W1EWM1_ECOLX            Unreviewed;      1186 AA.
AC   W1EWM1;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=ATP-dependent helicase HrpA {ECO:0000313|EMBL:CDL26511.1};
OS   Escherichia coli ISC7.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=1432555 {ECO:0000313|EMBL:CDL26511.1, ECO:0000313|Proteomes:UP000019199};
RN   [1] {ECO:0000313|EMBL:CDL26511.1, ECO:0000313|Proteomes:UP000019199}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISC7 {ECO:0000313|EMBL:CDL26511.1,
RC   ECO:0000313|Proteomes:UP000019199};
RA   Barisic I., Mitteregger D., Hirschl A.M., Noehammer C., Wiesinger-Mayr H.;
RT   "Antibiotic resistance diversity of beta-lactamase producers in the General
RT   Hospital Vienna.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDL26511.1}.
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DR   EMBL; CBWN010000058; CDL26511.1; -; Genomic_DNA.
DR   AlphaFoldDB; W1EWM1; -.
DR   Proteomes; UP000019199; Unassembled WGS sequence.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR024590; HrpA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010222; RNA_helicase_HrpA.
DR   NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR   Pfam; PF11898; DUF3418; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000313|EMBL:CDL26511.1};
KW   Helicase {ECO:0000313|EMBL:CDL26511.1};
KW   Hydrolase {ECO:0000313|EMBL:CDL26511.1};
KW   Nucleotide-binding {ECO:0000313|EMBL:CDL26511.1}.
FT   DOMAIN          1..136
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          160..330
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   1186 AA;  136068 MW;  34011A8F6DFA2F21 CRC64;
     MELGRGIKGL IGHTQPRRLA ARTVANRIAE ELKTEPGGCI GYKVRFSDHV SDNTMVKLMT
     DGILLAEIQQ DRLLMQYDTI IIDEAHERSL NIDFLLGYLK ELLPRRPDLK IIITSATIDP
     ERFSRHFNNA PIIEVSGRTY PVEVRYRPIV EEADDTERDQ LQAIFDAVDE LSQESPGDIL
     IFMSGEREIR DTADALNKLN LRHTEILPLY ARLSNSEQNR VFQSHSGRRI VLATNVAETS
     LTVPGIKYVI DPGTARISRY SYRTKVQRLP IEPISQASAN QRKGRCGRVS EGICIRLYSE
     DDFLSRPEFT DPEILRTNLA SVILQMTALG LGDIAAFPFV EAPDKRNIQD GVRLLEELGA
     ITTDEQASAY KLTPLGRQLS QLPVDPRLAR MVLEAQKHGC VREAMIITSA LSIQDPRERP
     MDKQQASDEK HRRFHDKESD FLAFVNLWNY LGEQQKALSS NAFRRLCRTD YLNYLRVREW
     QDIYTQLRQV VKELGIPVNS EPAEYREIHI ALLTGLLSHI GMKDADKQEY TGARNARFSI
     FPGSGLFKKP PKWVMVAELV ETSRLWGRIA ARIDPEWVEP VAQHLIKRTY SEPHWERAQG
     AVMATEKVTV YGLPIVAARK VNYSQIDPAL CRELFIRHAL VEGDWQTRHA FFRENLKLRA
     EVEELEHKSR RRDILVDDET LFEFYDQRIS HDVISARHFD SWWKKVSRET PDLLNFEKSM
     LIKEGAEKIS KLDYPNFWHQ GNLKLRLSYQ FEPGADADGV TVHIPLPLLN QVEESGFEWQ
     IPGLRRELVI ALIKSLPKPV RRNFVPAPNY AEAFLGRVKP LELPLLDSLE RELRRMTGVT
     VDREDWHWDQ VPDHLKITFR VVDDKNKKLK EGRSLQDLKD ALKGKVQETL SAVADDGIEQ
     SGLHIWSFGQ LPESYEQKRG NYKVKAWPAL VDERDSVAIK LFDNPLEQKQ AMWNGLRRLL
     LLNIPSPIKY LHEKLPNKAK LGLYFNPYGK VLELIDDCIS CGVDQLIDAN GGPVWTEEGF
     AALHEKVRAE LNDTVVDIAK QVEQILTAVF NINKRLKGRV DMTMALGLSD IKAQMGGLVY
     RGFVTGNGFK RLGDTLRYLQ AIEKRLEKLA VDPHRDRAQM LKVENVQQAW QQWINKLPPA
     RREDEDVKEI RWMIEELRVS YFAQQLGTPY PISDKRILQA MEQISG
//