ID   W1F274_ECOLX            Unreviewed;       697 AA.
AC   W1F274;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Nondeblocking aminopeptidase YpdE (X-X-[^PR]-specific) {ECO:0000313|EMBL:CDL27783.1};
OS   Escherichia coli ISC7.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=1432555 {ECO:0000313|EMBL:CDL27783.1, ECO:0000313|Proteomes:UP000019199};
RN   [1] {ECO:0000313|EMBL:CDL27783.1, ECO:0000313|Proteomes:UP000019199}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISC7 {ECO:0000313|EMBL:CDL27783.1,
RC   ECO:0000313|Proteomes:UP000019199};
RA   Barisic I., Mitteregger D., Hirschl A.M., Noehammer C., Wiesinger-Mayr H.;
RT   "Antibiotic resistance diversity of beta-lactamase producers in the General
RT   Hospital Vienna.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M42 family.
CC       {ECO:0000256|ARBA:ARBA00006272}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDL27783.1}.
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DR   EMBL; CBWN010000103; CDL27783.1; -; Genomic_DNA.
DR   AlphaFoldDB; W1F274; -.
DR   Proteomes; UP000019199; Unassembled WGS sequence.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd01092; APP-like; 1.
DR   CDD; cd05638; M42; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR   Gene3D; 2.40.30.40; Peptidase M42, domain 2; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR008007; Peptidase_M42.
DR   InterPro; IPR023367; Peptidase_M42_dom2.
DR   PANTHER; PTHR32481; AMINOPEPTIDASE; 1.
DR   PANTHER; PTHR32481:SF0; AMINOPEPTIDASE YPDE-RELATED; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF05343; Peptidase_M42; 1.
DR   SUPFAM; SSF101821; Aminopeptidase/glucanase lid domain; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW   ECO:0000313|EMBL:CDL27783.1}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670}.
FT   DOMAIN          4..125
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          134..306
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
SQ   SEQUENCE   697 AA;  75971 MW;  3CD95F817861BD32 CRC64;
     MTLLASLRDW LKAQQLDAVL LSSRQNKQPH LGISTGSGYV VISRESAHIL VDSRYFVEVE
     ARAQGYQLHL LDATNTLTTI VNQIIADEQL QTLGFEGQQV SWETAHRWKS ELNAKLVSAT
     PDVLRQIKTP EEVEIIRLAC GIADRGAEHI RRFIQAGMSE REIAAELEWF MRQQGAEKAS
     FDTIVASGWR GALPHGKASD KIVAAGEFVT LDFGALYQGY CSDMTRTLLV NGEGVSAESH
     PLFDVYQIVL QAQLAAISAI RPGVRCQQID DAARRVITEA GFGDYFGHNT GHAIGIEVHE
     DPRFFTAGHH DATARHVADR GAGDLFARAR GRAHRRCCAG YPARRRSALR HAENSVAHGR
     GIMDLSLLKA LSEADAIASS EQEVRQILLE EADRLQKEVR FDGLGSVLIR LNESTGPKVM
     ICAHMDEVGF MVRSISREGA IDVLPVGNVR MAARQLQPVR ITTREECKIP GLLDGDRQGN
     DVSAMRVDIG ARSYDEVMQA GIRPGDRVTF DTTFQVLPHQ RVMGKAFDDR LGCYLLVTLL
     RELHDAELPA EVWLVASSSE EVGLRGGQTA TRAVSPDVAI VLDTACWAKN FDYSAANHRQ
     IGNGPMLVLS DKSLIAPPKL TAWIETVAAE IGVPLQADMF SNGGTDGGAV HLTGTGVPTV
     VMGPATRHGH CAASIADCRD IFADAATFIC PYSTSYP
//