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Database: UniProt
Entry: W1H2L8_KLEPN
LinkDB: W1H2L8_KLEPN
Original site: W1H2L8_KLEPN 
ID   W1H2L8_KLEPN            Unreviewed;       311 AA.
AC   W1H2L8;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   25-OCT-2017, entry version 27.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
OS   Klebsiella pneumoniae ISC21.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=1432558 {ECO:0000313|EMBL:CDL53109.1, ECO:0000313|Proteomes:UP000019189};
RN   [1] {ECO:0000313|EMBL:CDL53109.1, ECO:0000313|Proteomes:UP000019189}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISC21 {ECO:0000313|EMBL:CDL53109.1,
RC   ECO:0000313|Proteomes:UP000019189};
RA   Barisic I., Mitteregger D., Hirschl A.M., Noehammer C.,
RA   Wiesinger-Mayr H.;
RT   "Antibiotic resistance diversity of beta-lactamase producers in the
RT   General Hospital Vienna.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CDL53109.1}.
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DR   EMBL; CBWQ010000857; CDL53109.1; -; Genomic_DNA.
DR   EnsemblBacteria; CDL53109; CDL53109; CDL53109.
DR   Proteomes; UP000019189; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019189};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019189}.
FT   DOMAIN        8    210       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      219    288       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND      16     23       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   311 AA;  35311 MW;  ED5AF8B4E40EF8E0 CRC64;
     MADNPGGAYN PLFLYGGTGL GKTHLLHAVG NGIVARKPNA KVVYMHSERF VQDMVKALQN
     NAIEEFKRYY RSVDALLIDD IQFFANKERS QEEFFHTFNA LLEGNQQIIL TSDRYPKEIN
     GVEDRLKSRF GWGLTVAIEP PELETRVAIL MKKADENDIR LPGEVAFFIA KRLRSNVREL
     EGALNRVIAN ANFTGRAITI DFVREALRDL LALQEKLVTI DNIQKTVAEY YKIKVADLLS
     KRRSRSVARP RQMAMALAKE LTNHSLPEIG DAFGGRDHTT VLHACRKIEQ LREESHDIKE
     DFSNLIRTLS S
//
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