ID W1ND49_9GAMM Unreviewed; 568 AA.
AC W1ND49;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Potassium:proton antiporter {ECO:0000313|EMBL:ERL52980.1};
GN Name=cvrA {ECO:0000313|EMBL:ERL52980.1};
GN ORFNames=BJB45_17015 {ECO:0000313|EMBL:ERL52980.1};
OS Halomonas huangheensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=1178482 {ECO:0000313|EMBL:ERL52980.1, ECO:0000313|Proteomes:UP000019113};
RN [1] {ECO:0000313|EMBL:ERL52980.1, ECO:0000313|Proteomes:UP000019113}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BJGMM-B45 {ECO:0000313|EMBL:ERL52980.1,
RC ECO:0000313|Proteomes:UP000019113};
RA Miao C., Wan Y., Jin W.;
RT "draft genome of Halomonas huanghegensis, strain BJGMM-B45T.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERL52980.1}.
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DR EMBL; AVBC01000014; ERL52980.1; -; Genomic_DNA.
DR RefSeq; WP_021817608.1; NZ_CP013106.1.
DR AlphaFoldDB; W1ND49; -.
DR STRING; 1178482.AR456_09690; -.
DR KEGG; hhu:AR456_09690; -.
DR PATRIC; fig|1178482.3.peg.665; -.
DR eggNOG; COG3263; Bacteria.
DR OrthoDB; 9810759at2; -.
DR Proteomes; UP000019113; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 6.10.140.1330; -; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR PANTHER; PTHR32507:SF7; K(+)_H(+) ANTIPORTER NHAP2; 1.
DR PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019113};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022449}.
FT TRANSMEM 56..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 403..483
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 568 AA; 61027 MW; 13C7748CAD85DB60 CRC64;
MDIINSLFLF AGTLIALSVL ASRLSAMAGV PLLVLFLVLG MLAGEEGVLG INFDNYSLAF
IIGHLALAMI LLDGGLRTRL TTFRVGFRPA LGLATIGVFI TSGLVGLISM WVFDLTLMQG
LLVGAIVGST DAAAVFSMLS GSGLNLNERV AATLEIESGT NDPMAIFLTL VLVESLVGGV
GTPVEMLLLF TQQFAVAIIL GLGGGWLSAR LLSWLDLAPG LYSLLALALG MCVFGMTSAL
GGSGFLAIYL TGLMIGNRPG RHLNFILPVH DGLAWLSQIG LFLVLGLLVT PSALFDVILP
ASIVALALIF IARPLAVIIT LKPFFRFRWR EVIFISWVGL RGAVPIVLAI FPVIGGVENS
QLYFNVAFAV VLLSLLIQGG SLPWMARRMR VMVPNTAEPN YRGPLGILPE NDFEMFVYRV
ENPDLEGVPI RLMRFPSGAL ISALFRKHVM LHPKGSTQLK VDDVICVIGR NDDLPALNRL
FDGEAKLKQR KDFFGTFTLD GGASMRDVAD AYGLTLSPAE AGLTLGHFLA LRVGGYPVVG
DDVDWHGIHW VISGMQGNRI THVGIRLY
//
