ID W1PG66_AMBTC Unreviewed; 552 AA.
AC W1PG66;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Peroxisomal membrane protein PEX14 {ECO:0000256|ARBA:ARBA00029502, ECO:0000256|RuleBase:RU367032};
DE AltName: Full=Peroxin-14 {ECO:0000256|ARBA:ARBA00029691, ECO:0000256|RuleBase:RU367032};
GN ORFNames=AMTR_s00058p00192040 {ECO:0000313|EMBL:ERN06664.1};
OS Amborella trichopoda.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Amborellales; Amborellaceae; Amborella.
OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERN06664.1, ECO:0000313|Proteomes:UP000017836};
RN [1] {ECO:0000313|Proteomes:UP000017836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24357323;
RG Amborella Genome Project;
RT "The Amborella genome and the evolution of flowering plants.";
RL Science 342:1241089-1241089(2013).
CC -!- FUNCTION: Component of the PEX13-PEX14 docking complex, a translocon
CC channel that specifically mediates the import of peroxisomal cargo
CC proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms
CC a large import pore which can be opened to a diameter of about 9 nm.
CC Mechanistically, PEX5 receptor along with cargo proteins associates
CC with the PEX14 subunit of the PEX13-PEX14 docking complex in the
CC cytosol, leading to the insertion of the receptor into the organelle
CC membrane with the concomitant translocation of the cargo into the
CC peroxisome matrix. {ECO:0000256|RuleBase:RU367032}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC {ECO:0000256|RuleBase:RU367032}.
CC -!- SIMILARITY: Belongs to the peroxin-14 family.
CC {ECO:0000256|ARBA:ARBA00005443, ECO:0000256|RuleBase:RU367032}.
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DR EMBL; KI393888; ERN06664.1; -; Genomic_DNA.
DR RefSeq; XP_006844989.1; XM_006844926.2.
DR AlphaFoldDB; W1PG66; -.
DR STRING; 13333.W1PG66; -.
DR EnsemblPlants; ERN06664; ERN06664; AMTR_s00058p00192040.
DR GeneID; 18434863; -.
DR Gramene; ERN06664; ERN06664; AMTR_s00058p00192040.
DR KEGG; atr:18434863; -.
DR eggNOG; KOG2629; Eukaryota.
DR HOGENOM; CLU_038637_1_0_1; -.
DR OMA; FHWSHAI; -.
DR OrthoDB; 358337at2759; -.
DR Proteomes; UP000017836; Unassembled WGS sequence.
DR GO; GO:1990429; C:peroxisomal importomer complex; IBA:GO_Central.
DR GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0016560; P:protein import into peroxisome matrix, docking; IBA:GO_Central.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR025655; PEX14.
DR InterPro; IPR006785; Pex14_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23058; PEROXISOMAL MEMBRANE PROTEIN PEX14; 1.
DR PANTHER; PTHR23058:SF0; PEROXISOMAL MEMBRANE PROTEIN PEX14; 1.
DR Pfam; PF17733; DUF5572; 1.
DR Pfam; PF04695; Pex14_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367032};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140, ECO:0000256|RuleBase:RU367032};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU367032};
KW Reference proteome {ECO:0000313|Proteomes:UP000017836};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367032}.
FT DOMAIN 54..98
FT /note="Peroxisome membrane anchor protein Pex14p N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF04695"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..473
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 552 AA; 59488 MW; 424D40857C09DFD1 CRC64;
MATDSSAPGL GNEKAGTPGV EPSKPTGDYE NGANVGATNE NGGKSVFVNS EPMREDQVQN
AIKFLSHPKV QGSPVVFRRS FLERKGLTKE EIDEAFRRVP DPPSNASTTQ VATSTQEGQL
QSALTVQPQP PVHTLQPAAV TTMTVPTPQK SGFQWSHIAL AVGLFAASGA CTGLLFKNAV
VPRLKSWIRK VVSEEDELEK KDQLKPRPID EAAAAAKAAA AAAAEVARAS QEMLHAKNEE
GKYFEAFTKL LEVQVEEMKT MRNTICNLEG IRENPRVLDQ QISKQFHSES GRPLSAPASI
QPAGGAPHSQ QFMDVMAMVQ RGEKPPGIRE INDKVPNATQ PLTNSRLVPK SKPWEDTSRV
QPSSIYISQT ETKVVDSPAS GQGAYYANGS ATQTQYRQPL RNGTPMAEQQ WWKQKPEPNP
SYSFNPDRGA NVTITEAEPE NDGLQTQHSW APSKESLPRR AWVPPPPPPV AMPEAADAIR
RPRSSGWVEG AGDERSTSSL GIGVEQDGPS ETGVLGSVKY DNSEVYGGTS AVDEDGSGKG
LDTIVPLETE AQ
//
