ID W1PZG0_AMBTC Unreviewed; 258 AA.
AC W1PZG0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Translocon-associated protein subunit alpha {ECO:0000256|RuleBase:RU368074};
DE Short=TRAP-alpha {ECO:0000256|RuleBase:RU368074};
DE AltName: Full=Signal sequence receptor subunit alpha {ECO:0000256|RuleBase:RU368074};
GN ORFNames=AMTR_s00041p00203840 {ECO:0000313|EMBL:ERN13451.1};
OS Amborella trichopoda.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Amborellales; Amborellaceae; Amborella.
OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERN13451.1, ECO:0000313|Proteomes:UP000017836};
RN [1] {ECO:0000313|Proteomes:UP000017836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24357323;
RG Amborella Genome Project;
RT "The Amborella genome and the evolution of flowering plants.";
RL Science 342:1241089-1241089(2013).
CC -!- FUNCTION: TRAP proteins are part of a complex whose function is to bind
CC calcium to the ER membrane and thereby regulate the retention of ER
CC resident proteins. May be involved in the recycling of the
CC translocation apparatus after completion of the translocation process
CC or may function as a membrane-bound chaperone facilitating folding of
CC translocated proteins. {ECO:0000256|RuleBase:RU368074}.
CC -!- SUBUNIT: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-
CC gamma. {ECO:0000256|RuleBase:RU368074}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115, ECO:0000256|RuleBase:RU368074}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115,
CC ECO:0000256|RuleBase:RU368074}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- DOMAIN: Shows a remarkable charge distribution with the N-terminus
CC being highly negatively charged, and the cytoplasmic C-terminus
CC positively charged. {ECO:0000256|RuleBase:RU368074}.
CC -!- SIMILARITY: Belongs to the TRAP-alpha family.
CC {ECO:0000256|RuleBase:RU368074}.
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DR EMBL; KI392588; ERN13451.1; -; Genomic_DNA.
DR RefSeq; XP_006851984.1; XM_006851922.2.
DR AlphaFoldDB; W1PZG0; -.
DR STRING; 13333.W1PZG0; -.
DR EnsemblPlants; ERN13451; ERN13451; AMTR_s00041p00203840.
DR GeneID; 18441696; -.
DR Gramene; ERN13451; ERN13451; AMTR_s00041p00203840.
DR KEGG; atr:18441696; -.
DR eggNOG; KOG1631; Eukaryota.
DR HOGENOM; CLU_095145_0_0_1; -.
DR OMA; FNFHIQN; -.
DR OrthoDB; 1220667at2759; -.
DR Proteomes; UP000017836; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR005595; TRAP_alpha.
DR PANTHER; PTHR12924:SF0; TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA; 1.
DR PANTHER; PTHR12924; TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT; 1.
DR Pfam; PF03896; TRAP_alpha; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU368074};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368074};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368074};
KW Reference proteome {ECO:0000313|Proteomes:UP000017836};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU368074};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368074};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368074}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..258
FT /note="Translocon-associated protein subunit alpha"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004807893"
FT TRANSMEM 194..213
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368074"
SQ SEQUENCE 258 AA; 28115 MW; E47CF902E5965797 CRC64;
MAASATLRVF IMALLFLSSP FLTVVRCQGE GESDVEGVEA VESGDLGIVG DDFQDSVEAV
FGSAPGVDTI CLFPKNPGKV VPAGEETELL VGVNNEGESP LKVLTMRATL HLPFDHKLLV
QNLTLQEFYN ASVPLSVQST FPYIFAVNKY LQPGSFDLVG TIMYEVDEQQ YQSVFYNGTI
EVVEAGGFVS VESVFLFTLG LALIGLFGLW IYGQIQNISK KTKRVTKVEV GTKTTDASMD
EWLQGTAFTQ SNKSKKKK
//
