ID W1Q964_OGAPD Unreviewed; 480 AA.
AC W1Q964;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 1 {ECO:0000256|RuleBase:RU364059};
DE AltName: Full=Mediator complex subunit 1 {ECO:0000256|RuleBase:RU364059};
GN ORFNames=HPODL_01474 {ECO:0000313|EMBL:ESW97375.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ESW97375.1, ECO:0000313|Proteomes:UP000008673};
RN [1] {ECO:0000313|EMBL:ESW97375.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
RN [2] {ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RA Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT "Genome sequence of the methylotrophic yeast Hansenula polymorpha DL1.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364059}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364059}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC {ECO:0000256|ARBA:ARBA00006210, ECO:0000256|RuleBase:RU364059}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESW97375.1}.
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DR EMBL; AEOI02000009; ESW97375.1; -; Genomic_DNA.
DR RefSeq; XP_013933460.1; XM_014077985.1.
DR AlphaFoldDB; W1Q964; -.
DR STRING; 871575.W1Q964; -.
DR GeneID; 25770935; -.
DR KEGG; opa:HPODL_01474; -.
DR HOGENOM; CLU_568687_0_0_1; -.
DR OMA; TEMISRI; -.
DR OrthoDB; 1983516at2759; -.
DR Proteomes; UP000008673; Chromosome VI.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR InterPro; IPR019680; Mediator_Med1.
DR Pfam; PF10744; Med1; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU364059};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364059};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364059};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364059}.
FT DOMAIN 17..234
FT /note="Mediator complex subunit Med1"
FT /evidence="ECO:0000259|Pfam:PF10744"
SQ SEQUENCE 480 AA; 54496 MW; 99499DB0DDE7CDE9 CRC64;
MPSIDTELIA PLSRISEILL KRPGRVTVDG IKRLANIYGF ETFSDVLAMN EQNDLVFAFS
DGRSASPEGR DGTQIERLSL SGKILLIDID FQDGHVKNVA LSSAISIESI DARSYDFVEG
FGDFVKVERV LYENLQAATL DNFNKNLRLL GQLDRLSVPA PFDLFNTFNL LTYNLLKAAE
AEKQQHRQDP QDALTESEAA ADLACGVQGF GQVLVNYDDK IGLFVKYWHD DRFLPGLPHP
DYLLHFKIAE SPRLENAESD NTKRVIEWYD GEWKPDVNLE FLVLELCPPV WVPEDLLLEL
NLEEYELLGP DNSVFNSTAD VLDGFYKEVN EEYSHRFSDA KGSKHEVFFL TGCKFVKLYK
VKLARLEKLR PLVCGLRSWC LVNNLIRNLV RREHREAESQ QAEELWLNDM VKDNLDILKQ
GQAATGPVQN VTSVSIQTLA QHEIELEVKG VHMKVLDGKV ECSDRLAARL VTKTEHLWLD
//
