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Database: UniProt
Entry: W1Q986_OGAPD
LinkDB: W1Q986_OGAPD
Original site: W1Q986_OGAPD 
ID   W1Q986_OGAPD            Unreviewed;       869 AA.
AC   W1Q986;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   07-JUN-2017, entry version 17.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=HPODL_01470 {ECO:0000313|EMBL:ESW97371.1};
OS   Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 /
OS   NRRL Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Pichiaceae; Ogataea.
OX   NCBI_TaxID=871575 {ECO:0000313|EMBL:ESW97371.1, ECO:0000313|Proteomes:UP000008673};
RN   [1] {ECO:0000313|Proteomes:UP000008673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC   {ECO:0000313|Proteomes:UP000008673};
RA   Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA   Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT   "Genome sequence of the methylotrophic yeast Hansenula polymorpha
RT   DL1.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ESW97371.1}.
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DR   EMBL; AEOI02000009; ESW97371.1; -; Genomic_DNA.
DR   RefSeq; XP_013933456.1; XM_014077981.1.
DR   EnsemblFungi; ESW97371; ESW97371; HPODL_01470.
DR   GeneID; 25770931; -.
DR   Proteomes; UP000008673; Chromosome VI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008673};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008673};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    443    467       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    488    506       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    566    583       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    595    619       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    658    677       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    800    825       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      112    139       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   869 AA;  99533 MW;  D82D6014EE5E271F CRC64;
     MSTESKEAIF RSADMLLVQF YIASEISRDC VSVLGQLGNV QFRDMNQHVN AFQRSFVKEI
     RRLDNTQRQL RYLDNVIKKQ QVHVPVVSWD HLVVPSGKYT ADPSRGPSKS QIDDLVEVVE
     HYEQNIRHMD ENYEQLVNSS ASLLEHRLVL QGTRRFFDNR LSLELADDNS PLSHLHEPED
     ETDQLLMDDR LLENGHHGEA AELNIMGSTM NFICGTIESS KFLTLQRILW RVLRGNLYIN
     HVPIEEPILD PKTNQHKDKY IFLIFTHGET LISRCKKIVE SLDGTLYPVD SDYEVFNSQI
     NEINTKIRDL NEVTEHTRDR LLLELKEVAA DIERWKIEIA KEKSIYSVLN LFNYDQTRRC
     LIAEGWIPAN DLGLIKSCLR EVTETSGTDI NSVVNVINTN KTPPTFHRTN KFTEAFQSII
     DAYGIATYQE VNPGLAAVVT FPFMFAIMFG DVGHGTILFL AALVLVLNER KIGAMKNRDE
     IFDMAYTGRY ILVLMGVFSI YTGFLYNDVF SKSMTFFKSG WKWPDTWKEG DTITGTQRGV
     YPIGLDPAWH GTENNLLFTN SYKMKLSILM GFAHMSYSFY FSLVNYKFFN SRVDVIGNFV
     PGLLFMQSIF GYLSLTIIYK WCVDWIKIGK APPSLLNMLI NMFLSPGTIE DQLYPGQGFV
     QVVLVLIALV CVPWLLLYKP LTLKRMNAQS VELGYTDLHE YNQAVQLAAN EEVSPTQSHD
     NSLGEDFFLV DDSDEPEEHF EFGDVMIHQV IHTIEFCLNC VSHTASYLRL WALSLAHNQL
     SAVLWDMTIS NSFVSYKEKG FAGCVMVFLL FGMWFVLTVC ILVVMEGTSA MLHSLRLHWV
     EAMSKFFEGE GYAYTPFSFY KILTESEAV
//
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