ID W1Q9W9_OGAPD Unreviewed; 1219 AA.
AC W1Q9W9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Nuclear protein STH1/NPS1 {ECO:0000313|EMBL:ESW97143.1};
DE EC=3.6.4.12 {ECO:0000313|EMBL:ESW97143.1};
GN ORFNames=HPODL_01249 {ECO:0000313|EMBL:ESW97143.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ESW97143.1, ECO:0000313|Proteomes:UP000008673};
RN [1] {ECO:0000313|EMBL:ESW97143.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
RN [2] {ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RA Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT "Genome sequence of the methylotrophic yeast Hansenula polymorpha DL1.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESW97143.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEOI02000009; ESW97143.1; -; Genomic_DNA.
DR RefSeq; XP_013933228.1; XM_014077753.1.
DR AlphaFoldDB; W1Q9W9; -.
DR STRING; 871575.W1Q9W9; -.
DR GeneID; 25770712; -.
DR KEGG; opa:HPODL_01249; -.
DR eggNOG; KOG0386; Eukaryota.
DR eggNOG; KOG1827; Eukaryota.
DR HOGENOM; CLU_000315_15_3_1; -.
DR OMA; VNYISHT; -.
DR OrthoDB; 5482994at2759; -.
DR Proteomes; UP000008673; Chromosome VI.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0042393; F:histone binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17996; DEXHc_SMARCA2_SMARCA4; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014012; HSA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029295; SnAC.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR10799:SF1012; NUCLEAR PROTEIN STH1_NPS1; 1.
DR PANTHER; PTHR10799; SNF2/RAD54 HELICASE FAMILY; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF14619; SnAC; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM01314; SnAC; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51204; HSA; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ESW97143.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 270..346
FT /note="HSA"
FT /evidence="ECO:0000259|PROSITE:PS51204"
FT DOMAIN 457..622
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 770..958
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1125..1195
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 390..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1051..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 39..66
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 260..310
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1051..1085
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1219 AA; 140946 MW; 14E0A9ED9AFE9426 CRC64;
MSDEVQNGKT AVEIAYPSTV HDVHRLLSRL AVSNKDIEKK KILKILQQLA KERQKYEEKS
IDLEKSWAQN KEVVDLDLLK VQVMAFNLLS KDLDLPLEVQ TKLVGETDVE SLKGQANDNG
IPVDFNEKAK LFGLDPHKTV PDPEIHSAGS TLGESLVKQK VESRIHELEN LPANIGLYDA
SSIENDLEKS ASDILDNVDE IKIRALNELK ALKLLPEQKQ LRRKLIQDCL TSVVHQKNKY
GSDSFRAFKR SFSIRDKQKI EQTSRLAEKL QEQQRREKEE LEHDYQTHKV NKLAAIFDEV
RDELEEKRNA RHFLAKALQH FHSQVEKDES KKLERIAKQR LAALRSNDEE AYMQLLTKTK
DTRLHHLIQQ TNNFLDSLAN AVKVQQDEAR ARSLQDRAEE GLEPLQEDTE EDADARREKI
DYYEVAHRVK EKIEKQPSLL VGGTLKEYQL KGLEWMVSLY NNNLNGILAD EMGLGKTIQS
ISLITYLIES KKERGKFLVI VPLSTITNWT LEFERWAPSV KTIVYKGTQH QRKQLQYEVR
SGNFSVLLTT YEYVIRDRPL LCKFKWAHMI IDEGHRMKNA SSKLSLTLTQ YYHTRNRLIL
TGTPLQNNLP ELWALLNFVL PKVFNSVKSF DEWFNTPFAN TGHQDKLELS EEESLLIIRR
LHKVLRPFLL RRLKKDVEKD LPDKVERVVK CKLSGLQSCL YKQMLNHNAL FVGVGTQGAT
KTGLRGLNNK IMQLRKVCNH PYVFEEVEDI VNPSRLTTDL IWRSSGKFEL LDRVLPKFKA
SGHKVLIFFQ MTQVMDIMED YLRFRDMKYM RLDGSTKADD RQDMLKDFNA PDSEYFCFLL
STRAGGLGLN LQTADTVIIF DTDWNPHQDL QAQDRAHRIG QKNEVRILRL ITEDSVEEVI
LERAHQKLDI DGKVIQAGKF DNKSSAEEQE AFLKRLLEAE KMKAEEAEND DLDDEELNEI
LARNEDEKKL FAEIDQARIR DDQKLDGPRL MSYEELPPVF KEDITLHLEK DKPDAGIKRE
RKQVVYDDGL TEEQWLDAMD AENDTVEAAA LRKRETMRQR RAKRSAGADE EEEETPRKRR
STKSATPMSE ESFVEEEEDD DAGEEPFVEL CEGLLQKLVN ATDENGRSRS ELFMTVPSKK
LYPDYYQIVK KAVAIKDLQK GLKKGSIVDY QQFKEELQQM FDNAKLYNED GSLVYNDAIE
LEKIAKDELG RIDAELGEE
//
