ID W1QAD0_OGAPD Unreviewed; 377 AA.
AC W1QAD0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Sterol 24-C-methyltransferase {ECO:0000313|EMBL:ESW97795.1};
DE EC=2.1.1.41 {ECO:0000313|EMBL:ESW97795.1};
GN ORFNames=HPODL_01877 {ECO:0000313|EMBL:ESW97795.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ESW97795.1, ECO:0000313|Proteomes:UP000008673};
RN [1] {ECO:0000313|EMBL:ESW97795.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
RN [2] {ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RA Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT "Genome sequence of the methylotrophic yeast Hansenula polymorpha DL1.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Erg6/SMT family. {ECO:0000256|ARBA:ARBA00038188,
CC ECO:0000256|PROSITE-ProRule:PRU01022}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESW97795.1}.
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DR EMBL; AEOI02000009; ESW97795.1; -; Genomic_DNA.
DR RefSeq; XP_013933880.1; XM_014078405.1.
DR AlphaFoldDB; W1QAD0; -.
DR STRING; 871575.W1QAD0; -.
DR GeneID; 25771333; -.
DR KEGG; opa:HPODL_01877; -.
DR eggNOG; KOG1269; Eukaryota.
DR HOGENOM; CLU_039068_5_3_1; -.
DR OMA; AFNKAMH; -.
DR OrthoDB; 275921at2759; -.
DR Proteomes; UP000008673; Chromosome VI.
DR GO; GO:0003838; F:sterol 24-C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901617; P:organic hydroxy compound biosynthetic process; IEA:UniProt.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR030384; MeTrfase_SMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR013705; Sterol_MeTrfase_C.
DR PANTHER; PTHR44068:SF1; HYPOTHETICAL LOC100005854; 1.
DR PANTHER; PTHR44068; ZGC:194242; 1.
DR Pfam; PF13847; Methyltransf_31; 1.
DR Pfam; PF08498; Sterol_MT_C; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51685; SAM_MT_ERG6_SMT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01022,
KW ECO:0000313|EMBL:ESW97795.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673};
KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01022};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01022}.
FT DOMAIN 78..373
FT /note="SAM-dependent methyltransferase Erg6/SMT-type"
FT /evidence="ECO:0000259|PROSITE:PS51685"
SQ SEQUENCE 377 AA; 42969 MW; 3E2866889C5B2181 CRC64;
MSSEIKLAPK DYEKDKEFAK ALHGKDAASA TGMSAWVKKD KEAQKVAMEG YFKHWDGKTD
EETEKSRLED YSTLTKHYYN LVTDFYEYGW GSSFHFSRYY KGEPFRQACA RHEHYLALKM
GITENMKVLD VGCGVGGPAR EITRFTDCEI VGLNNNDYQI ERANNYAKKL KLDHKLSFVK
GDFMQMDFEP ETFDAVYSIE ATVHAPVLEG VYGQIYKVLK PGGVFGVYEW VMTDEYDETN
EEHRKIAYGI EVGDGIPKMY KREVAEKALK NVGFEIEYTR DLADAGDEIP WYYPLSGDFK
YVQTIGDLWT FFRTSTVGRK ITTGSVGLME KLGIAPKGSV KVTEALEDAA VYLVEGGKRK
LFTPMMLYIV RKPLDAK
//
