ID W1QBP8_OGAPD Unreviewed; 680 AA.
AC W1QBP8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Transcription factor BYE1 {ECO:0000256|ARBA:ARBA00021616};
GN ORFNames=HPODL_01851 {ECO:0000313|EMBL:ESW97768.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ESW97768.1, ECO:0000313|Proteomes:UP000008673};
RN [1] {ECO:0000313|EMBL:ESW97768.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
RN [2] {ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RA Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT "Genome sequence of the methylotrophic yeast Hansenula polymorpha DL1.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of transcription elongation.
CC {ECO:0000256|ARBA:ARBA00002311}.
CC -!- SIMILARITY: Belongs to the BYE1 family.
CC {ECO:0000256|ARBA:ARBA00011050}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESW97768.1}.
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DR EMBL; AEOI02000009; ESW97768.1; -; Genomic_DNA.
DR RefSeq; XP_013933853.1; XM_014078378.1.
DR AlphaFoldDB; W1QBP8; -.
DR STRING; 871575.W1QBP8; -.
DR GeneID; 25771307; -.
DR KEGG; opa:HPODL_01851; -.
DR eggNOG; KOG1634; Eukaryota.
DR HOGENOM; CLU_024990_1_0_1; -.
DR OMA; RTHKGDI; -.
DR OrthoDB; 5491784at2759; -.
DR Proteomes; UP000008673; Chromosome VI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.472.30; Transcription elongation factor S-II, central domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR012921; SPOC_C.
DR InterPro; IPR003618; TFIIS_cen_dom.
DR InterPro; IPR036575; TFIIS_cen_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11477:SF20; PROTEIN PARTNER OF SNF, ISOFORM B; 1.
DR PANTHER; PTHR11477; TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF20826; PHD_5; 1.
DR Pfam; PF07744; SPOC; 1.
DR Pfam; PF07500; TFIIS_M; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00510; TFS2M; 1.
DR SUPFAM; SSF46942; Elongation factor TFIIS domain 2; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51321; TFIIS_CENTRAL; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 60..119
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 227..354
FT /note="TFIIS central"
FT /evidence="ECO:0000259|PROSITE:PS51321"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..200
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..449
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 680 AA; 77459 MW; AC5F66E7D5D8F179 CRC64;
MSTEIRRSSR KTKGVNSRLE DLDKIGEPTP RPKKRTASSK ANGQKKKQLK KAVKVPEKEE
VRCLPCGSHD LNYNEDEDER GVMIQCDKCE TWQHAKCMLG TDNEDSIPDD YVCNLCDPGN
PKYQDLELAL SPDDYYKERF PDRIDEIDDQ EEEDFEDAGA VYGESDEEYD GNGEKEEEDG
DEEEEEEGDD ADDPEEPGEL EEPEEKVKKP VRRPQKVVRK KVDRNKTRQS VVSQFAKKLQ
GHIPEDHKLL EQMDVSSAAE EIASGLENAL FEAFPPPNKR SESMSPGYLN KSRTLLFNLD
KSNLSDKVLS GQYTYEQIVH LTPEEMMRDD YKEFADAVRK QSINQSVITN TLEKVKIKRT
HKGEEIVEED YQFDDIDSRT ADESRLNEIE KLQEEKRLQD EENEASASPP PTANLNANIM
TTIANDFDDE EQEQDQTGEG PEETFDNDDD FDKILNGTKD VVPTPPESQA VVNDDEEDYD
PARNFDVDET LWNGILSFAP VADVQTTIRF HAASTYDSTE DKVAKARKIV GDFVARHNRL
DIEGRLDAQK AVGYLWEIIN TRDLYLVELV PFASPHLSEF ENQQTQTQFR KLWEYFNSRN
KYGVIAYKPA YIKDSYLVAL DTTRTEQEGL PRYFSHFNMT SLHGARERLF AVFVAKKDLS
AAPSGAATAN LDQILSGLAA
//
