ID W1QEZ7_OGAPD Unreviewed; 495 AA.
AC W1QEZ7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Succinate-semialdehyde dehydrogenase, mitochondrial {ECO:0000256|ARBA:ARBA00019842};
DE EC=1.2.1.24 {ECO:0000256|ARBA:ARBA00013051};
DE AltName: Full=NAD(+)-dependent succinic semialdehyde dehydrogenase {ECO:0000256|ARBA:ARBA00030806};
GN ORFNames=HPODL_01029 {ECO:0000313|EMBL:ESX00147.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ESX00147.1, ECO:0000313|Proteomes:UP000008673};
RN [1] {ECO:0000313|EMBL:ESX00147.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
RN [2] {ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RA Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT "Genome sequence of the methylotrophic yeast Hansenula polymorpha DL1.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESX00147.1}.
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DR EMBL; AEOI02000006; ESX00147.1; -; Genomic_DNA.
DR RefSeq; XP_013934953.1; XM_014079478.1.
DR AlphaFoldDB; W1QEZ7; -.
DR STRING; 871575.W1QEZ7; -.
DR GeneID; 25770495; -.
DR KEGG; opa:HPODL_01029; -.
DR eggNOG; KOG2451; Eukaryota.
DR HOGENOM; CLU_005391_5_1_1; -.
DR OMA; CTHEEVF; -.
DR OrthoDB; 216092at2759; -.
DR Proteomes; UP000008673; Chromosome IV.
DR GO; GO:0009013; F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity; IEA:UniProtKB-EC.
DR CDD; cd07103; ALDH_F5_SSADH_GabD; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR43353; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43353:SF5; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673}.
FT DOMAIN 36..491
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 266
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 495 AA; 53681 MW; 4CAD65464FD5ACDB CRC64;
MNPLRFCRRL SGLRARERLV EPRALINGQF KEFPGFDVVN PANQQVLAQV SDTPLEEVEF
AVSVAARAFG DYRSVPVHAR ARILSNWHNL MLEHEQDLAR LVTLENGKPL ADSLGEVRYA
ASFFKWFAEE AVRCYGDTIP SATPSNRMYT QWQPVGPVGI ITPWNFPLAM ITRKLGAALA
AGCTSVIKPA AETPMSAMAM AVLGVEAGVP DGVVNFVPVA HSKTAKVGEL FCKSPDLRKV
SFTGSTRVGK LLMEQSSSTL KRLSMELGGN APFVVFEDAD LEKAAAGFMS CKFRSSGQTC
VCANRIFVHD KVYAEFVAMV ADLIDKNTRM GPGIDPTVTH GPLIHENALA KVEALVEDAV
EKGAKVVRGG RRRPDLGALF YDLTLLSDVT PKMDIFHTEA FGPVAPVIRF SSEDEVVQQA
NNTEVGLAAY FYTENNSRAW RVAEKLQAGM VGVNTGLISE AALPFGGVGE SGFGREGSKY
GLAEYSELKT VVVGI
//
