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Database: UniProt
Entry: W1QGW3_OGAPD
LinkDB: W1QGW3_OGAPD
Original site: W1QGW3_OGAPD 
ID   W1QGW3_OGAPD            Unreviewed;       801 AA.
AC   W1QGW3;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   25-APR-2018, entry version 20.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=HPODL_00265 {ECO:0000313|EMBL:ESX00851.1};
OS   Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 /
OS   NRRL Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Pichiaceae; Ogataea.
OX   NCBI_TaxID=871575 {ECO:0000313|EMBL:ESX00851.1, ECO:0000313|Proteomes:UP000008673};
RN   [1] {ECO:0000313|Proteomes:UP000008673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC   {ECO:0000313|Proteomes:UP000008673};
RA   Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA   Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT   "Genome sequence of the methylotrophic yeast Hansenula polymorpha
RT   DL1.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ESX00851.1}.
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DR   EMBL; AEOI02000005; ESX00851.1; -; Genomic_DNA.
DR   RefSeq; XP_013935685.1; XM_014080210.1.
DR   EnsemblFungi; ESX00851; ESX00851; HPODL_00265.
DR   GeneID; 25769739; -.
DR   Proteomes; UP000008673; Chromosome III.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:EnsemblFungi.
DR   GO; GO:0034622; P:cellular protein-containing complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0071469; P:cellular response to alkaline pH; IEA:EnsemblFungi.
DR   GO; GO:0006797; P:polyphosphate metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008673};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008673};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    405    429       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    450    467       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    527    549       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    561    582       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    621    639       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       98    125       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   801 AA;  91559 MW;  C95C6819C2ED2DA4 CRC64;
     MSVEPEAIFR SAEMSLVQLY IPAEIGRTAI YSLGKLGLVE FRDLNKKVNA FQRSFVNEIR
     RLDNVERQYR YFQSEMDNRG LKLIEYDSTP ETLTTSQLDE IVEDAQLLED RISQLSNASE
     DLLKQQVDLK QYQQVLAATD RYFQHVETAD LIDLGEPEFL ENGGVRDANF ITGVIPRAKV
     EVLERILWRV LRGNLFITSA EIGQRLYDIK TKNYVDKNSF IIFAHGELIL SRVRKICESL
     DADLYFVDQE TKRRAQQMRE VNDKLADVTN VLESTELTLE TELSAVASEL DLWWKAVKLE
     KSVYSVMNLC HYDQARRCLI GEGWVPSDDF DKVKSVLEEI TTKYSDSPEE SFPIVVNTVE
     TTRTPPTYHK VNKFTAAYQA MCDAYGVATY REVNPGLPTV ATFPFMFAIM FGDLGHGFIM
     FLAALALVLN EKKIAKLKRD EIFDMAYSGR YILLMMGFFS MYTGFLYNDV FSLSTTFFKS
     GWKWPESWKE GETITGTQTG VYPFGLDPAW HGTENNLLFT NSYKMKLSIL MGFIHMSYSY
     AFSLVNYVYF KSKIDIIGNF IPGLLFMQGI FGYLSLCIVY KWCVDWIKIN KPAPSLLNML
     INMFLAPGKI EDELYPGQST VQVTLLLIAL VSVPCLLLIK PLHFKFSHSH HYENLPSESS
     SNNLLTNLNL DDEEEHEEHT FGDVMIHQVI HTIEFCLNCV SHTASYLRLW ALSLAHAQLS
     SVLWSMTIAN SFAATGLFGS VFVFLMFGMW FVLTVAILVV MEGTSAMLHA LRLHWVESMS
     KYFEGEGIAY EPFSFKVVLD I
//
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