ID W1QHH2_OGAPD Unreviewed; 1228 AA.
AC W1QHH2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Putative ATP-dependent RNA helicase {ECO:0000313|EMBL:ESX01055.1};
DE EC=3.6.4.- {ECO:0000313|EMBL:ESX01055.1};
GN ORFNames=HPODL_00464 {ECO:0000313|EMBL:ESX01055.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ESX01055.1, ECO:0000313|Proteomes:UP000008673};
RN [1] {ECO:0000313|EMBL:ESX01055.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
RN [2] {ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RA Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT "Genome sequence of the methylotrophic yeast Hansenula polymorpha DL1.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESX01055.1}.
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DR EMBL; AEOI02000005; ESX01055.1; -; Genomic_DNA.
DR RefSeq; XP_013935889.1; XM_014080414.1.
DR AlphaFoldDB; W1QHH2; -.
DR STRING; 871575.W1QHH2; -.
DR GeneID; 25769935; -.
DR KEGG; opa:HPODL_00464; -.
DR eggNOG; KOG0947; Eukaryota.
DR HOGENOM; CLU_002902_1_4_1; -.
DR OMA; CGSDITR; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000008673; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 2.30.30.1160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR InterPro; IPR048727; Ski2_beta-barrel.
DR InterPro; IPR040801; Ski2_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF21409; Ski2_beta-barrel; 1.
DR Pfam; PF17911; Ski2_N; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ESX01055.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ESX01055.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 288..446
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 547..746
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 494..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 770..797
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1228 AA; 139778 MW; 57648CBBC29C2718 CRC64;
MTTQLLDVLH DLKVGPKDNN VWLDPTTKTA TPPPPVSEEG VLADIKRTYL SPTNELPWDL
LDKFQQVPEV GTQDRERFYR SMLTIPPTLK RTTVRFQRSG IEGSIVSYKE TFDRTILESG
NSAVTSLSVK RKFGGKDDAI KGNSGFLPFQ PGGLTANEEP KDSTKFLHRD ENGLLDIPQG
LSRGLALKDG THTDLTELEQ KQVSDEQETV QDQEPEIIQE ADVEDEISKF IPASMLTRPS
KRKPALPPKR EWAHVVDVNH AIPNFDELVP NPARTWPFEL DTFQKEAVYH LEKNDSVFVA
AHTSAGKTVV AEYAIALANR NMTKTIYTSP IKALSNQKFR DFKESFDDVD VGVITGDVQI
NPEANCLIMT TEILRSMLYR GADLIRDVEF VIFDEVHYVN DIERGVVWEE VIIMLPEHIK
VVLLSATVPN TYEFASWVGR TRQKDIYVIS TSKRPVPLEI FVWAKDDIFK LIDANGSFQQ
KNFRLHEDKL LKKKDVPDTN DKGKSGAVVR GGARGGARGG RGGARGGSTM SGKMFKRDGP
NKNSWHNLVT FLQKKDLMPA VIFVFSKKRC EEYADTLRGV NFCTAKEASQ IHMFIDKAVS
RLKKEDRELP QILKVREMLS RGIAVHHGGL LPIVKEIIEI LFSKTLIKVL FATETFAMGL
NLPTRTVVFS ELRKHDGTGY RNLLPGEFTQ MSGRAGRRGL DSTGTVIVMA YNQPLEEFAF
KEVTMGTATK LSSKFRLTYN MILNLLRIEA LRVEEMIKRS FGENTTQSLL PEHEIEIAKL
EKQLRDLKKQ NISEEDNAKL NLFYNTMEEM KEQYGDLVQE SMKLLYYQKR LKVGRLVVYR
DRDTNQSYPA VTARWSNGDD KITLLTLDVQ QSSKNQFNCV YTTNFGQPYV AKFFSKWKAG
TNFKFIDVPL NDIEFVGAYS VRSYINGIIN KDPKSISDFK TEVGQLLRYQ RKWGELDWTA
FQNPNMIEIL TRIDELRDTV MNCFADEKFD SLVEAEYPTF MNRKNIEKRI ESLKSLMSEE
NLELLPDYEQ RLEVLKQLEF VNDQLTVTLK GRVACEINFG FELIVTELVF ENILGTFTSE
EIVALLSCFV YDGKRGNDEG PAPLCTPRLE SGKDKIVEIV EQVMKVSNEN KIILTAEEEQ
FLENNRFGLV NVVYEWARGQ SFKDIMELSN DENEAEGTIV RVITRLDEVC RVVMNCALIV
GDSELHMKMG EAQEKIKRDI VFCASLYL
//
