ID W1QHY5_OGAPD Unreviewed; 562 AA.
AC W1QHY5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN ORFNames=HPODL_00609 {ECO:0000313|EMBL:ESX01210.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ESX01210.1, ECO:0000313|Proteomes:UP000008673};
RN [1] {ECO:0000313|EMBL:ESX01210.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
RN [2] {ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RA Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT "Genome sequence of the methylotrophic yeast Hansenula polymorpha DL1.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|RuleBase:RU004273};
CC -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC {ECO:0000256|RuleBase:RU004273}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESX01210.1}.
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DR EMBL; AEOI02000005; ESX01210.1; -; Genomic_DNA.
DR RefSeq; XP_013936044.1; XM_014080569.1.
DR AlphaFoldDB; W1QHY5; -.
DR STRING; 871575.W1QHY5; -.
DR GeneID; 25770080; -.
DR KEGG; opa:HPODL_00609; -.
DR eggNOG; KOG0375; Eukaryota.
DR HOGENOM; CLU_004962_6_2_1; -.
DR OMA; KTTGFPA; -.
DR OrthoDB; 1488111at2759; -.
DR Proteomes; UP000008673; Chromosome III.
DR GO; GO:0033192; F:calmodulin-dependent protein phosphatase activity; IEA:InterPro.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0097720; P:calcineurin-mediated signaling; IEA:InterPro.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR043360; PP2B.
DR InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR PANTHER; PTHR45673; SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED; 1.
DR PANTHER; PTHR45673:SF1; SERINE_THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED; 1.
DR Pfam; PF00149; Metallophos; 1.
DR PRINTS; PR00114; STPHPHTASE.
DR SMART; SM00156; PP2Ac; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU004273, ECO:0000313|EMBL:ESX01210.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673}.
FT DOMAIN 182..187
FT /note="Serine/threonine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS00125"
FT REGION 523..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 562 AA; 64501 MW; 8EFEBB8316B7BAC3 CRC64;
MSPLQNLKAH ENSVKIENAL RHVKKRDEAA APGDPTVYVD EQGETFITTD RIVKTISPPS
FRIPADAEVF PDGRKPDYKF LMHHFKQEGR LSEQQLTYIL QESAAIFEQE PNMLKVPCPA
TVVGDIHGQY YDLCKMLNMC GDPAKTQYLF LGDYVDRGDY SMECLILLLA MKINFPKSFW
ILRGNHETKR MTEHFTFKRE CAVKYSLAIY KEALNTFKMM PFCAVLNEQF FCCHGGLSPE
LERLSDISKI NRFRYDFPSR GLFSDIMWSD PAPEYDTEVL SPTDYDSYFR DNYERHCSYY
YSYHAVCHFL EKNNLLSVIR AHQAQDAGYR MYRKNEATGF PSVITLFSAP NYCGTYRNKA
AALIYDGSTF NIKQFVATDS PYHLPDFMDV FEWSLPFVSE KVLDILVSIL NICTEDELEE
ETVVARDVVK SLQDVPETSP ETTLAAVTGP ATGVSPLEAR ASLRKKLLSI GRMSRMFNIL
REEAEKVEHL KTYSGGKLPR GVLMDGREEL HNRLKSFSEA READLQNEAL PPSAEELERI
EEERQRKARE YIEGADQWSH SA
//
