ID W1QL81_OGAPD Unreviewed; 1212 AA.
AC W1QL81;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Cell division control protein 25 {ECO:0000313|EMBL:ESX03570.1};
GN ORFNames=HPODL_00067 {ECO:0000313|EMBL:ESX03570.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ESX03570.1, ECO:0000313|Proteomes:UP000008673};
RN [1] {ECO:0000313|EMBL:ESX03570.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
RN [2] {ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RA Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT "Genome sequence of the methylotrophic yeast Hansenula polymorpha DL1.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESX03570.1}.
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DR EMBL; AEOI02000001; ESX03570.1; -; Genomic_DNA.
DR RefSeq; XP_013936986.1; XM_014081511.1.
DR AlphaFoldDB; W1QL81; -.
DR STRING; 871575.W1QL81; -.
DR GeneID; 25769542; -.
DR KEGG; opa:HPODL_00067; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002171_1_0_1; -.
DR OMA; IIEPKPR; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000008673; Chromosome I.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000313|EMBL:ESX03570.1};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 14..81
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 766..899
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 940..1183
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 110..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1212 AA; 139566 MW; B722F4C596544144 CRC64;
MGDEPAANKP SRATVTPVCV ATVTRYFDGQ NDPALLSLMV DDIVYVLNTP NSRWWDGILI
DPIGNVTRGW FPPSHTRIIQ QGTPLQPSVS TVRDERRTLE SLNVPKNISF SSTASAQTPH
RESFQSTRSG DRSQSVTMAS AEEINSYFSQ STSQPSFNFL PVWVPEITQD DEFVYHNSAL
NVYAKELPLI SADYVDHGSA LEKTDLSRFN GLDVVPIDAK ETAADSESQA ERTYDQPQNR
DTIVDCLTDT NGKLWHSPDM FYFSPMDVTN WPDLYKKFRY LVNMCLEAIS KNSRELFLVH
LNSISETVTL FHLASNMGAK DLERNGVADG VRENLHKITS SLSQLAINGN LHFVGSKHSQ
YYLGRDDAAD EELSSTDELD HGSQTSRGSE TFLRRAERDA VKLIKRASSL KETFLRLRYT
NQVDAENLPL VYPRFFKGRF HAGNFANPFD DLGSALHSSE SLFIDPHSHK NNVLLDDEAI
EYLTDYKTKA CEILENVVQV LSTQIPRDVK YKNFIEDRNL NIVTLIYHSV PSLNRFLNIL
ESIDFTIFIM VNRLARKERL RNERVAEDDD PESANRLFYE TTSKQLEPVL TEFVELKQSL
HDTLSDLIMD AQNITVDDPE VFEGMKEEEM FYDKTILSLK TEQFSRALVA NLNEKDFRDL
NDGEYLYDSN LKLRATISKA LQQFDLIIMS TTQLKEERQS ILNYCTRLMN TDFSVASLFV
AERHNTMISS LSQSEYSYGR RKSRDTETEL PWFLDADDEE QSVIFDINGI KGGPAGGLVS
RLVNPTHDND DEFKETMLAM FVTFMTPVAF FDALMDRYNV QMPEGLSYEE YSIWVEKKLK
RQRDEVLRTF AKLFSTAWLV QYSSSELRTK WDVFVDSNNV DAKLAQLGRL VMAMKTQDEW
FAEFGHGNPE PKPFEGRPPV PLMLGKNLRN TTKLRLRDID SMEFARQITL IQFELFHKID
KFDLLARSYR FSRIFKHSEP VGSKSIANFV RNCNVITHFV IYMILRQRDI QARAENIKYF
IIVADKLLKL RNYSSMTAII SGLSSTSISR LKKTWVLVPK HLVANFEKMD QLMSIGKNYS
EYRSILKFVN EDSEPCLPFL GMYLSDLRFL TDGNSDYLHN NRNLVNFGKR LSIYRTIQEV
IKFNAKAYHF EKIDELWTYF YDMWEQLPDD DKLYNISLKL EPMVSLVNQQ DNEKRARGVD
ARVFKRNVPA RL
//
