ID   W1TQE9_9ACTO            Unreviewed;       491 AA.
AC   W1TQE9;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Permease {ECO:0008006|Google:ProtNLM};
GN   ORFNames=Q618_VCMC00001G1196 {ECO:0000313|EMBL:ETI83615.1};
OS   Varibaculum cambriense DORA_20.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Varibaculum.
OX   NCBI_TaxID=1403948 {ECO:0000313|EMBL:ETI83615.1, ECO:0000313|Proteomes:UP000018843};
RN   [1] {ECO:0000313|EMBL:ETI83615.1, ECO:0000313|Proteomes:UP000018843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DORA_20 {ECO:0000313|Proteomes:UP000018843};
RA   Brown C.T., Sharon I., Thomas B.C., Castelle C.J., Morowitz M.J.,
RA   Banfield J.F.;
RT   "A Varibaculum cambriense genome reconstructed from a premature infant gut
RT   community with otherwise low bacterial novelty that shifts toward anaerobic
RT   metabolism during the third week of life.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETI83615.1}.
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DR   EMBL; AZMI01000001; ETI83615.1; -; Genomic_DNA.
DR   AlphaFoldDB; W1TQE9; -.
DR   STRING; 184870.HMPREF1862_01062; -.
DR   PATRIC; fig|1403948.3.peg.220; -.
DR   eggNOG; COG2252; Bacteria.
DR   Proteomes; UP000018843; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1904823; P:purine nucleobase transmembrane transport; IEA:UniProt.
DR   InterPro; IPR045018; Azg-like.
DR   InterPro; IPR006043; NCS2.
DR   PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR   PANTHER; PTHR43337:SF1; XANTHINE_URACIL PERMEASE C887.17-RELATED; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018843};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        43..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        127..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        158..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        223..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        291..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        399..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        427..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        468..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   491 AA;  51223 MW;  FB5E52530F0C7FB0 CRC64;
     MPLVADWKVI LSSQDTAKKP DSSLDRFFKI SERGSTVGRE VRGGLVTFFA MAYILVVNAA
     ILGVAAPKDI SQSSIAAGTA LVACVMTLLM GLVANFPLAV ASGMGLNAVV AFTLANPEAL
     GLSYQEAMGL IFWEGVAITI LVLTGFREAV FKAVPAQLKT AISVGIGLFI AFVGLINAGI
     IRPGGTPVQL GVNGSLVGWP ALVFCFGLIV IVVLYVRKVQ GAILIGIVSA TVLAFIVQAF
     THLGSRAADE EAVSAWASNV PQLQGSPVSL PDLSTIGAID FFGPFTNPHT TAVGVVLLIF
     SLMLADFFDT MGTMVAVGAG ANLLDKDGNP PKTREILLID SLSAMAGGLG GVSSNTSFVE
     STSGVGEGAR TGLASVVTGL LFGVSMFIAP LVELVPAEAA STALVFVGFL MMVNVRDIEW
     TRADVAIPAF MTIMMMPFAY SITVGIGFGF ITYVVVKIAS GRISRIHPLM WVVSVLFVIY
     FSLGPIQSLL S
//